Term
|
Definition
Amphotericin B (Amphocin®)
Nystatin (Mycostatin®)
Natamycin (Natacyn®)
MOA: Binds to sterols in the fungal cell membrane |
|
|
Term
|
Definition
Amphocin®, Fungizone®
Used topically or parenterally
Spectrum: Cryptococcus neoformans, Blastomyces dermatitidis, Coccidiodes immitis, Histoplasma capsulatum, Aspergillus fumigatus, Candida albicans
Polyene Antifungals |
|
|
Term
|
Definition
Mycostatin®
Too toxic to be used systemically
Polyene Antifungals |
|
|
Term
|
Definition
Natacyn®
Used for fungal infections of the eye
Polyene Antifungal |
|
|
Term
|
Definition
Ketoconazole (Nizoral®)
Itraconazole (Sporonox®)
Fluconazole (Diflucan®)
Voriconazole (Vfend®)
MOA: Inhibit fungal P450 enzymes that are necessary for biosynthesis of ergosterol. Ergosterol is needed to build fungal cell membranes. If fungus can’t make their cell membrane their contents leak out and they will die. |
|
|
Term
|
Definition
Nizoral®
SE: Hepatotoxicity
Formulations: Oral & Topical
Spectrum: Dermatophytes, Cryptococcus neoformans, Blastomyces dermatitidis, Coccidioides immitis, Histoplasma capsulatum, Aspergillus fumigatus, Candidas albicans
Azole |
|
|
Term
|
Definition
Sporonox®
SE: Less hepatotoxic than Ketoconazole
Spectrum: Broader than Ketoconazole
Azole |
|
|
Term
|
Definition
Diflucan®
Given PO & IV
Inhibitor of CYP 450
Spectrum: Candidas, Cryptococcus meningitis
Azole |
|
|
Term
|
Definition
Vfend®
Given PO
Inhibits CYP 450
Spectrum: Aspergillus fumigatus
Azole |
|
|
Term
Squalene Epoxidase Inhibitors |
|
Definition
Naftifine (Naftin®)
Terbinafine (Lamisil®)
MOA: Inhibits squalene epoxidase
Used for treating skin and nail infections |
|
|
Term
|
Definition
Naftin®
Squalene Epoxidase Inhibitor |
|
|
Term
|
Definition
Lamisil®
Squalene Epoxidase Inhibitor |
|
|
Term
Inhibitors of Cell Wall Biosynthesis
(Echinocandins) |
|
Definition
Caspofungin (Cancidas®)
Anidulafungin (Eraxis®)
Micafungin (Mycamine®)
MOA: Inhibits enzyme beta-1,3-glucan synthase
Treats life threatening fungal infections caused by Candida and Aspergillus infections |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Flucytosine (Ancobon®)
Griseofulvin (Fulvicin®)
Haloprogin (Halotex®)
Ciclopirox (Penlac®)
Undecylenic Acid
|
|
|
Term
|
Definition
Ancobon®
MOA: metabolized to 5-fluorouracil by cytosine deaminase. 5-flurouracil inhibits thymidylate synthetase, which is the enzyme that converts uracil to thymine. Thymine is used to make DNA. Therefore, flucytosine inhibits the production of thymine which inhibits DNA
Other Antifungal |
|
|
Term
|
Definition
Fulvicin®
MOA: Binds to keratin to allow old "infected" skin to slough off easily
Affects microsomal enzymes
Other Antifungal |
|
|
Term
|
Definition
Halotex®
MOA: Mechanism is unclear but it appears to lead to nonspecific metabolic disruptions
Other Antifungal |
|
|
Term
|
Definition
Penlac®
Used primarily for nail infections
MOA: Inhibits metal-dependent enzymes withing the fungi
Other Antifungal |
|
|
Term
|
Definition
No Brand Name
MOA: Interacts with components in the fungal cell membrane
Usually used for athletes foot, not for use on mucus membranes
Other Antifungal |
|
|
