Shared Flashcard Set

Details

antifungals
pharm ch. 48
18
Pharmacology
Graduate
10/19/2009

Additional Pharmacology Flashcards

 


 

Cards

Term
interactions between this drug and cell membrane components can result in the formation of pores lined by hydrophilic groups present in the drug molecule
Definition
nystatin
Term
which statement about fluconazole is accurate?
Definition
it inhibits demethylation of lanosterol
Term
tx for candida in immunocompromised pts
Definition
stop current antibiotics and start amphotericin B
Term
if amphotericin B is administered, the pt should be premedicated w/
Definition
diphenhydramine, ibuprofen, prednisone
Term
dose-limiting toxicity of amphotericin B is
Definition
renal tubular acidosis
Term
candida is a major cause of nosocomial blood-stream infection. the opportunistic fungal infection in this pt could have been prevented by administration of
Definition
nothing in immunocompromised pts
Term
pt w/ coccidioides immitis, what is DOC
Definition
fluconazole
Term
which drug is least likely to be effective in the treatment of esophageal candidiasis if it is used by the oral route
Definition
griseofulvin
Term
which statement about flucytosine is accurate
Definition
it is bioactivated by fungal cytosine deaminase
Term
serious cardiac effects have occurred when this drug was taken by pts using the antihistamines astemizole or terfenadine
Definition
ketoconazole
Term
which drug is most appropriate for oral use in vaginal candidiasis
Definition
fluconazole
Term
regarding the clinical use of liposomal formulations of amphotericin B, which statement is accurate
Definition
they decrease the nephrotoxicity of amphotericin B
Term
which drug used IV for disseminated and mucocutaneous candida infections is an inhibitor of synthesis of fungal cell wall component
Definition
caspofungin
Term
amphotericin B clinical use
Definition
systemic fungal infections, fungal meningitis, UTIs
Term
nystatin clinical use
Definition
intestinal or oral candida
Term
clinical use of ketoconozole
Definition
paracoccidioides brasiliensis, pharyngeal and chronic mucocutaneous candida
Term
use of fluconazole
Definition
systemic histoplasmosis, and other mycosis, opportunistic fungals
Term
itraconazole use
Definition
aspergillus, local tinea or candidal infections
Supporting users have an ad free experience!