Term
| Polyenes (have a lot of double bonds) |
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Definition
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Term
| isolated from Streptomyces nodosus (used systemically) |
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Definition
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|
Term
| isolated from S. noursei (not used systemically) |
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Definition
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Term
|
Definition
| Clotrimazole, Miconazole, Econazole, Tioconazole, Ketoconazole |
|
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Term
| Only Imidazole that is available for systemic use (others are for topical) |
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Definition
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|
Term
| Inhibit fungal C-14 demethylase in ergosterol biosynthesis (A P450 enzyme, accumulation of lanosterol |
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Definition
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Term
| five membered ring with 2 nitrogens in it |
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Definition
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|
Term
| five membered ring with 3 nitrogens in it |
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Definition
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Term
| Most commonly used to treat candidiasis resistant to nystatin; non-meningeal crytococcal disease |
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Definition
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Term
|
Definition
| Traconazole, Terconzole, Fluconazole |
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|
Term
| Lack of pH dependence on oral bioavailability, less effect on human steroid metabolism |
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Definition
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|
Term
| much weaker base than imidazole (pKa ~2) |
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Definition
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Term
| single-dose treatment for vaginal candidiasis; step-down therapy after amphotericin B |
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Definition
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Term
| "Pulse" treatment for onychomycosis |
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Definition
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Term
| Vaginal suppository for candidiasis |
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Definition
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|
Term
| Allylamines and related amines |
|
Definition
| Terbinafine, Naftidine, Butenafine |
|
|
Term
|
Definition
|
|
Term
| Inhibit squalence epoxidase (SQLE) in ergosterol synthesis; fungistatic activity limited to dermatophytes (not active against Candida sp) |
|
Definition
| Allylamines and related amines |
|
|
Term
| oral formulation available; requires LFTs to monitor hepatotoxicity |
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Definition
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|
Term
| converted by yeast cytosine deaminase then activated to 5-FdUMP; Irreversible inhibition of thymidylate synthase |
|
Definition
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|
Term
|
Definition
| fungistatic against Candida and Crytococcus; secondary resistance develops rapidly |
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