Term
| Candida, Trichosporon, Crytococcus, Saccaromyces spp. |
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Definition
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Term
| Epidermophyton, Microsporum, Trichophyton |
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Definition
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Term
| Histoplasma, Blastomyces, Coccidiodes spp. |
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Definition
| Dimorphic (yeast at 37 degrees, molds at 30-35 degress celcius) |
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Term
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Definition
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Term
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Definition
| Dermatophytes, Candida sp. |
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Term
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Definition
| restricted to gardeners/farmers |
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Term
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Definition
| Dimorphic fungi common in immunocompetent hosts, Opportunistic mycoses require immunocomprimised hosts |
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Term
| when you see these systemically you are almost always sure you are looking at an immunocompromised person |
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Definition
| Candida, Asperigillus, Trichospoon spp, Cryptococcus neoformons, etc |
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Term
| immunocompromised people mellitus |
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Definition
| HIV/AIDs, Hodgkin's disease, burns, diabetes |
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Term
| Drug-induced immunocompromised |
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Definition
| immunosuppressants, CTX, chronic corticosteroids |
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Term
| can cause immunocompromised systemic fungal infections |
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Definition
| Prostheses, IV access lines |
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Term
| complexes ergosterol to form hydrophilic pores through fungal membrane (kill fungal cells directly); cell leakage and lysis |
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Definition
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Term
| Polyenes broad spectrum of activity |
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Definition
| yeasts, dimorphics, zygomycetes |
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Term
| "swish and spit"--this is why you can use them as creams, not going to cross membranes; can swallow for espophageal fungi (isn't toxic cuz doesn't cross membranes) |
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Definition
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Term
| used almost exclusively in life threatening situations; probably the most important systemic antifungal agent in the world |
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Definition
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Term
| Amphotericin B infusion reactions |
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Definition
| fever, chills, N/V, thrombophlebitis |
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Term
| When using amphotericin B premedicate with these |
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Definition
| antipyretics, antiemetics, heparin, hydrocortisone |
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Term
| Metabolic disturbances by Amphotericin B, can be life threatening |
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Definition
| Hypokalemia, hypomagnesemia, acidosis |
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Term
| if you have a drug that decreases the blood supply into the kidney you are restricting oxygen to the kidney |
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Definition
| ischemic acute renal failure (Amp B) |
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Term
| drug that is directly toxic to those cells independent of blood supply |
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Definition
| nephrotoxic acute tubular necrosis |
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Term
| Hematological (Reversible) Amp B AE |
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Definition
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Term
| As an antifungal MOA, Amph B binds to ergosterol when available; nonetheless amph B still has effect on kidney stones |
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Definition
| Aggregation state hypothesis |
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Term
| Human membrane (cholesterol) |
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Definition
| Amp B plays with itself instead of a partner |
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Term
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Definition
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Term
| Topical use usually with nystatin |
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Definition
| oral suspension and tablets, vaginal suppositories (creams and tablets), dermatological cream and ointment |
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Term
| Imidazoles and triazoles broad spectrum of activity (but more limited than AMB |
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Definition
| Candida and Crytococcus spp (yeasts), dimorphics-limited coverage of molds |
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Term
| In sterol synthesis: all come from a common precursor of: |
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Definition
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Term
| enzyme used in a step of sterol synthesis |
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Definition
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Term
| highly hydrophobic in unionized state; moderately strong base; unionized form is unable to partition OUT of luminal membrane |
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Definition
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Term
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Definition
| CYP3A4/5 and androgen synthesis; also a P450 substrate |
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Term
| Major limitation of ketoconazole |
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Definition
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Term
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Definition
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