Term
| Antifungals are used to treat what 2 types of infections? |
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Definition
1. Systemic 2. Superficial |
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Term
| 2 types of systemic mycoses |
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Definition
1. opportunistic 2. non-opportunistic |
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Term
| examples of opportunistic infections |
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Definition
canditis, aspergillosis, cryptococcosis, mucormycosis |
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|
Term
| examples of non opportunistic infections |
|
Definition
sporotrichosis, blastomycosis, histoplasmosis, coccidiodomycosis |
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Term
|
Definition
Thrush, vaginal candidiasas, intertriginous candidal infection |
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Term
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Definition
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Term
| Interactions/Contraindications for Nystatin |
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Definition
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Term
|
Definition
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Term
| Azoles are DOC for what topical infection |
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Definition
|
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Term
| Interactions/Contraindications for Azoles |
|
Definition
affects P450 system = all involved in drug interactions! |
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|
Term
Terbinafine is what type of drug? |
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Definition
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Term
|
Definition
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Term
| Terbinafine is DOC for what type of infection |
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Definition
|
|
Term
Terbinafine possible drug interaction |
|
Definition
|
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Term
|
Definition
local topical irritation taste disturbances for systemic tx |
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Term
|
Definition
|
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Term
|
Definition
Skin/nail irritation, topical irritation |
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|
Term
| Systemic Infections drugs |
|
Definition
1. Azoles (Flucon, itracon, voricon) 2. Polyene (Amphotericin B) 2. Nucleoside (flucystosine) 4. Echinocandins (Caspo, Mica, Anidula-fungin) |
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Term
|
Definition
| inhibits cell wall synth -> leakage/permeability |
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|
Term
|
Definition
| Superficial and invasive infections |
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|
Term
| Absorption/metabolism of Fluconazole |
|
Definition
NOT dependant of acidity poorly metabolized |
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Term
|
Definition
1. GI 2. Incr. LFT's ***NO ENDOCRINE AE's |
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Term
|
Definition
broad spectrum Cutaneous and mucosal infections |
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|
Term
| Absorption of itraconazole |
|
Definition
| incr. w/ decr. gastric acid |
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|
Term
|
Definition
1. GI 2. Incr. LFT's, TG's K 3. CNS (HA) |
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|
Term
|
Definition
| interferes with cell wall synth |
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|
Term
| Administration Amphotericin B |
|
Definition
PARENTAL ONLY!!! broad spectrum -> All life threatening inf. |
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Term
|
Definition
1. Infusion related- fever, chills, m. spasm, V, HA, 2. Renal Tubular Acidosis (decr. K, Mg) |
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|
Term
what precautions should be taken when giving amphotericin b? |
|
Definition
| Slow infusion + antipyretics, histamines, steriods |
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|
Term
| systemic tx for topical infections |
|
Definition
1. griseofulvin 2. terbinafine |
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Term
|
Definition
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|
Term
| Administration Griseofulvin |
|
Definition
|
|
Term
|
Definition
1. Parasthesia 2. Photosensitivity 3. Hypersensitivity |
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|
Term
Drug interactions Griseofulvin |
|
Definition
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|
Term
| Drug interactions Terbinafine |
|
Definition
| Rifampin, Cimetidine, Cyclosporine |
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