Term
|
Definition
| forms pores in fungal wall by interacting with ergosterol |
|
|
Term
|
Definition
adverse effects:
azotemia (urea in blood), flush, chills, fever, phelbitis, headache, anemia, respiratory stridor,, reversible decreased renal function |
|
|
Term
|
Definition
| deamination to 5-FU inhibits fungal DNA synthesis |
|
|
Term
|
Definition
| only base analog antifungal |
|
|
Term
|
Definition
adverse effects:
reversible bone marrow suppression |
|
|
Term
|
Definition
similar to Amphotericin B
too toxic for parenteral use
foul taste, n/v/d |
|
|
Term
|
Definition
used in systemic infections (unlike nyastin)
causes renal dysfunction and fever |
|
|
Term
|
Definition
| very few side effects because human cells do not perform rxn |
|
|
Term
|
Definition
| inhibit enzyme in ergosterol synthesis |
|
|
Term
|
Definition
can cross BBB w/ inflammation
best drug for immunocompromised
(AIDS pts with histoplasmosis)
prophylactic |
|
|
Term
|
Definition
can cross BBB w/out inflammation
(cryptococcus meningitis in AIDS) |
|
|
Term
|
Definition
only antifunal routinely used systemically.
can interfere with steroid synthesis
not good for preggo/nursing & CNS infections |
|
|
Term
|
Definition
adverse effects:
Nausea, vomiting (it should be
administered with food). Heptatoxicity. Effects on host steroids. Fluconazole increases
plasma levels of phytoin, zidovudine, cyclosporine, and warfarin. |
|
|
Term
|
Definition
bacteriostatic
inhibits mitotic spindle formation (M-phase) |
|
|
Term
|
Definition
adverse effects:
rare but severe neuro disturbances
leukopenia and neutropenia |
|
|
Term
|
Definition
| Caspofungin, Micafungin, and Anidulafungin |
|
|
Term
|
Definition
inhibits glucan synthase = inhibits cell wall synthesis
(B 1 3 D glucan) |
|
|
Term
|
Definition
| Treats esophageal candidasis and candida abdominal infections |
|
|
Term
|
Definition
| tx pneumocystis carinii infection |
|
|
Term
|
Definition
inhibits fungal squalene monooxygenase
approved for tinea capitis |
|
|
