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ANTIFUNGAL
by Dr.Beevers
11
Pharmacology
Graduate
10/25/2009

Additional Pharmacology Flashcards

 


 

Cards

Term

AMPHOTERICINE B

 

polyenes

Definition

INJ/TOP

BROAD

ergosterol – pores

resistance possible

Term

NYSTATIN

polyene

Definition

ORAL/TOP

CANDIDAL

ergosterol – pores

resistance possible

Term

KETOCONAZOLE

 

 

AZOLES

Definition

ORAL/TOP

ergosterol – synth

H. sterol & cyt p450 INHIBIT

Resistance in long, cross

Term

CLOTRIMAZOL/MICONAZOL

 

AZOLES

Definition

TOP/VAGINA

Ergosterol – synth

Resistance in long, cross

Term

FLUCONAZOL

 

AZOLES

Definition

CNS/ORAL;

Ergosterol –synth

RENAL EXCRETE 75%

Resistance in long, cross

Term

TERBINAFINE (TOLNAFTATE)

 

ALLYLAMINE

Definition

Ergosterol – synth

ORAL/TOP

KERATINE BOUND (skin, hair, nail)

NO RESISTANCE

Term

ANIFULAFUNGIN

 

ECHINOCANDINS

Definition

INHIBIT b-Glucan Synth

INVASIVE CANDIDA

LONG LAST

RESISTANCE SLOW

IV

Term

MICAFUNGIN

 

ECHINOCANDINS

Definition

INHIBIT b-Glucan Synth

MUCOCUTANIOUS CANDIDA

RESISTANCE SLOW

IV

Term

CASPOFUNGIN

 

ECHINOCANDINS

Definition

INHIBIT b-Glucan Synth

BOTH CANDIDA TYPES

RESISTANCE SLOW

IV

Term

FLUCOCYTOCINE

 

ANTIMETABOLITES

Definition

DNA SYNTH INIBIT

RESISTANCE DEVELOP

COMBINATION USED

RENAL EXCRETION

Term

GRISEOFULVIN

 

BENZOFURAN

Definition

MT NOT FORM

LIVER ENZYME INCREASED

KERATINE BOUND, SKIN/HAIR/NAIL ONLY

NO RESISTANCE

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