Term
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Definition
| Antifungal- subQ/systemic. Fungicidal. binds to sterol moiety (ergosterol) present in membranes of sensitive fungi. |
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Term
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Definition
| Antifungal- subQ/systemic. Fungistatic. false nucleotide- inhibits thymidylate synthetase- stops formation of thymidylic acid, an essential DNA component. used in combo |
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Term
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Definition
| Antifungal- subQ/systemic. Fungicidal- static. blocks demethylation of lanosterol to ergosterol; supresses testosterone and cortisol synthesis. |
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Term
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Definition
| Antifungal- subQ/systemic. Fungistatic.locks demethylation of lanosterol to ergosterol. DOC for cyrptococcus neoformans, candidemia, hisoplasmosis. fewer endocrine side effects, excellent penetration into CSF. |
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Term
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Definition
| Antifungal- subQ/systemic. fungistatic. synthetic triazole. locks demethylation of lanosterol to ergosterol. no endocrine side effects, No CNS. AE- inhibits CYP 450, NV, rash, hypokalemia, HTN, edema, HA. TX onychomycosis |
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Term
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Definition
| Antifungal- cutaneous. Fungicidal. inhibits synthesis of ergosterol. TX onychomycosis |
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Term
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Definition
| Antifungal- cutaneous. Fungistatic. interacts with microtubules to disrupt mitotic spindles and thus inhibit mitosis. DOC severe tinea infections |
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Term
| DOC life threatening systemic mycoses |
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Definition
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Term
| drug interactions (block cyp450), GI, hepatic, gynecomastia, impotence, decreased libido, menstrual irregularities. CI in preggo |
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Definition
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Term
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Definition
antifungal- Inhibit synthesis of β (1,3)-D-glucan, essential fungal cell wall component
TX echinocandins |
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Term
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Definition
antifungal- Inhibit synthesis of β (1,3)-D-glucan, essential fungal cell wall component
TX echinocandins |
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Term
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Definition
antifungal- Inhibit synthesis of β (1,3)-D-glucan, essential fungal cell wall component
TX echinocandins |
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Term
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Definition
| Antifungal- similar to ampho B. Restricted treatment of candida infections- systemic toxicity. oral- swish and swallow. |
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Term
| Clotrimazole (lotrimin, mycelex) |
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Definition
| Antifungal- topical. tx cutaneous mycoses. rarely administered parenterally |
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Term
| Miconazole (monistat, micatin) |
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Definition
| Antifungal- topical. tx cutaneous mycoses.rarely administered parenterally |
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Term
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Definition
| Antifungal- topical. tx cutaneous mycoses. rarely administered parenterally |
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Term
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Definition
| Antiprotozoal- Disrupts DNA synthesis. DOC Trichomoniasis, amebiasis + luminal amebicide, giardiasis, entamoeba histolytica (not cysts). also used in combo for H, pylori. widely distributed body & CNS. DOC giardiasis |
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Term
| NV, epigastric distress, abd cramps, unpleasant metallic taste, oral moniliasis; neurologic toxicity, dizziness, vertigo, HA, numbness, parethesias; ETOH interaction. CI preggo, alcohol |
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Definition
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Term
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Definition
| Antiprotozoal- only effective against luminal forms of E. hystolytica & tapeworm. alternative therapy for cryptosporidiosis. |
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Term
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Definition
| Antiprotozoal- malaria. tissue schizonticide; eradicates primary exoerythrocytic forms of p. falciparum, p. vivax. eradicates secondary exoerythrocytic forms of recurring malarias p. vivax, p. ovale. Gametocidal for all four species. |
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Term
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Definition
| Antiprotozoal- malaria. inhibition of heme polymerization. DOC of erythrocytic p falciparum malaria. rapidly absorbed orally, accumulates. safe in preggo |
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Term
| GI upset, pruritus, HA, visual disturbances. caution with hepatic dysfunction, severe GI problems, neurologic or blood disorders, psoriasis or porphyria |
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Definition
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Term
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Definition
| antiprotozoal- malaria. tissue schizonticide. reserved for malarial strains resistant to other agents. |
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Term
| Cinchonism. NV, tinnitus, vertigo; can elevate digoxin levels; fetotoxic; hemolytic anemia |
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Definition
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Term
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Definition
| antiprotozoal- malaria. used for treatment/ prophylaxis of multi-drug resistant forms of p. falciparum. well absorbed oral, long t1/2. |
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Term
| ECG abnormalities & cardiac arrest if taken concurrently with quinine |
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Definition
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Term
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Definition
| antiprotozoal- malaria. blood schizonticide; inhibition of dihydrofolate reductase. effective against resistant p. falciparum. DOC for toxoplasmosis |
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Term
| Fansider (pyrimethamine + sulfadoxine) |
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Definition
| antiprotozoal- malaria. combination, synergistic. lower effective dosed of each drug, less development of resistance. toxicity limits use |
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Term
| severe skin reaction- erythema multiforme, stevens-johnson syndrome |
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Definition
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Term
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Definition
| reduced form of folic acid, does not require reduction by dihydrofolate reductase, not affected by blockage of dihydrofolate reductase |
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Term
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Definition
| DOC for patients with severe malaria |
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