Term
|
Definition
cell wall
cell membrane
tetrahydrofolic acid synthesis |
|
|
Term
|
Definition
cell membrane with ergesterol
chitin
beta-glucan
mannoproteins |
|
|
Term
| beta-glucan synthesis inhibitor |
|
Definition
echinocandian agents
caspofungin |
|
|
Term
|
Definition
invasive candidiasis
drug resistant aspergillosis |
|
|
Term
|
Definition
inhibition of transmembrane glucan synthase complex
cell wall looses integrity and cell lyses |
|
|
Term
|
Definition
|
|
Term
| ergasterol synthesis inhibitors |
|
Definition
azole derivatives
miconazole
fluconazole |
|
|
Term
|
Definition
broad spectrum
invasive infections |
|
|
Term
|
Definition
binds to ergasterol in fungal cell and causes a pore
loss of ions and other molecules is fatal |
|
|
Term
|
Definition
topical
mucocutaneous candidiasis |
|
|
Term
|
Definition
binds to ergasterol in fungal cell membranes and forms pore
loss of ions and molecules lethal to cell |
|
|
Term
ergasterol synthesis ihibitors
azole derivatives |
|
Definition
miconazole
ketoconazole
fluconazole |
|
|
Term
ergasterol synthesis inhibitor
allylamine |
|
Definition
|
|
Term
|
Definition
| anti-dermatrophytic agent |
|
|
Term
|
Definition
blocks ergasterol synthesis
inhibits formation of ergosterol precursor |
|
|
Term
| azole two chemical classes |
|
Definition
imidazoles (two Nitrogens in ring)
triazoles (three nitrogens in ring) |
|
|
Term
|
Definition
| broad spectrum anit-fungal |
|
|
Term
|
Definition
| blocks ergasterol synthesis |
|
|
Term
|
Definition
vaginal infections due to candida albicans
several fungal infections of skin |
|
|
Term
|
Definition
chronic mucocutaneous fungal infections
6-12 months therapy |
|
|
Term
|
Definition
|
|
Term
| inhibitor of THFA synthesis |
|
Definition
|
|
Term
|
Definition
| treatment and prophylaxis of PCP (pneumocystis pneumonia) |
|
|
Term
|
Definition
inhibits THFA synthesis and enzymes needed for purine synthesis
stops DNA and RNA synthesis |
|
|
