Term
| WHAT IS THE MECHANISM OF ACTION OF THIAZOLIDINEDIONES (TZDS)? |
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Definition
| PPAR (GAMMA) INCREASE THE SENSITIVITY OF INSULIN IN TISSUES. WORKS SIMILAR TO FIBRATES TO LOWER LIID LEVELS. MAIN EFFECT IS THE CHANGE GENE REGULATION. |
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Term
| WHAT IS THE ONSET OF THIAZOLIDINEDIIONES (TZDS)? |
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Definition
| DUE TO MOA, ONSET CAN BE WEEKS TO MONTHS |
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Term
| TZDS CAN BE BENEFICIAL IN THE PREVENTION OF WHAT? |
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Definition
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Term
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Definition
| ROSIGLITAZONE AND PIOGLITAZONE (ACTOS) |
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Term
| ROSIGLITAZONE IS RESTRICTED DIE TO WHAT? |
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Definition
| CV EFFECTS. MUST BE ON USER LIST. INCREASE INCIDENCE OF MI |
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Term
| WITH TZDS THE PATIENT IS EUGLYCEMIA. WHAT TYPE OF RISK FOR HYPOGLYCEMIA ARE THERE? |
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Definition
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Term
| WHAT ARE 4 SIDE EFFECTS OF TZDS? |
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Definition
| WEIGHT GAIN, CHF/EDEMA (OFTEN GIVEN WITH DIURETIC), INCREASED BONE FRACTURES, AND MI |
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Term
| WHAT OTHER MEDICATION DO WE TYPICALLY GIVE WITH TZDS? |
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Definition
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Term
| WHAT 4 THINGS DOES GLUCAGON-LIKE PEPTIDE-1 (GLP-1) DO? |
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Definition
| INCREASES INSULIN SECRETION, DECREASES GLUCAGON SECRETION, INCREASES UPTAKE OF GLUCOSE BY MUSCLES AND ADIPOSE TISSUE, INCREASES SATIETY (D/T AMYLIN). |
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Term
| HOW DOES SYNTHETIC GLP-1/DPP-4 INHIBITORS WORK? GLP-1 IS RAPIDLY BROKEN DOWN BY WHAT ENZYME? |
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Definition
| DIPEPTIDYL PEPTIDASE-4 (DPP-4). BY INHIBITING DPP-4, INCREASED GLP-1 HAS ANTIHYPERGLYCEMIA EFFECTS. |
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Term
| NAME ARE 2 DRUGS THAT ARE A GLP-1 ANALOG? |
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Definition
| EXENATIDE AND LIRAGLUTIDE (BOTH END IN TIDE) |
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Term
| HOW IS EXENATIDE ADMINISTERED? |
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Definition
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Term
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Definition
| FROM THE SALIVA OF GILA MONSTER |
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Term
| WHAT IS THE PEAK AND DURATION OF EXENATIDE? |
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Definition
| PEAK IS 2 HRS AND DURATION IS 10 HRS |
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Term
| WHAT ARE 3 SIDE EFFECTS ASSOCIATED WITH EXENATIDE? |
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Definition
| NAUSEA, VOMITING, PANCREATITIS |
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Term
| HOW IS LIRAGLUTIDE ADMINISTERED? |
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Definition
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Term
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Definition
| SITAGLIPTIN AND SAXAGLIPTIN |
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Term
| WHAT IS A DRUG THAT IS A AMYLIN ANALOG? |
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Definition
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Term
| WHAT IS THE PEAK AND DURATION OF PRAMLINTIDE? |
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Definition
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Term
| WHAT ARE 2 SIDE EFFECTS OF AMYLIN ANALOG? |
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Definition
| HYPOGLYCEMIA AND GI UPSET (B/C AMYLIN HAS GI ACTIONS) |
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Term
| WHAT 2 CLASSIFICATIONS OF ANTIDIABETICS CAUSE MORE PRONOUNCED HYPOGLYCEMIA? |
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Definition
| SULFONYLUREAS AND AMYLIN ANALOGS |
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Term
| HOW DOES SULFONYLUREAS INCREASE INSULIN SECRETION? |
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Definition
| BY CAUSING CELLULAR DEPOLARIZATION |
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Term
| TZDS INCREASE INSULIN SENSITIVITY THROUGH WHAT? |
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Definition
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Term
| WHAT DOES GLP-1 DO TO INSULIN? |
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Definition
| INCREASE INSULIN SECRETION |
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Term
| WHAT BREAKS DOWN GLP-1? WHAT HAPPENS IF YOU INHIBIT THAT ENZYME? |
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Definition
| DPP-4 BREAKS DOWN GLP-1. INHIBITING DPP-4 = MORE GLP-1 TO INCREASE INSULIN |
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