Term
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Definition
| sleectively inhibit reuptake 5-ht, no NE uptake. |
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Term
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Definition
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Term
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Definition
| inhbit areuptake of both ne and 5ht |
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Term
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Definition
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Term
| tircylic antidepresants moaa |
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Definition
| inhiit reuptaek of both ne and 5ht. itneract with variety of other receptors, hve broad range of side effects. snRIs have more specificity. |
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Term
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Definition
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Term
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Definition
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Term
| imiparmine efect and its metaabolite |
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Definition
| imipramine seratonin morehtan orep, its metabolite deipramine hasnorep more than seratonin. |
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Term
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Definition
| 5-ht2 antagonit, originally prodrug |
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Term
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Definition
| 5-ht2A antagonit, originally prodrug |
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Term
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Definition
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Term
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Definition
| acts like aamphetamine, may affect dopamine reuptake, heterocyclic antidepressant |
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Term
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Definition
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Term
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Definition
| common effect of tcas and hcas. |
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Term
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Definition
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Term
| msucarinic rceptor lockade |
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Definition
| occurs with all tcas. Atropine-like effects |
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Term
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Definition
| tcas cause hypotentsion, due to alpha adrenergic recptor lb ockade, depress cardiac produrction |
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Term
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Definition
| tcas and maois (some ssris) |
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Term
| depressedd dphase of bpad |
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Definition
| demands pharm itnerentsion, treated alognside lihium , neededor high rate of suicide |
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Term
| anxiety disorders treatment |
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Definition
| treat for both nxiety nadderpession, can use venlafaxine ,paroxetine |
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Term
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Definition
| ssris first line , can be switched to tca or maoi if not effective |
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Term
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Definition
| ssris seem uniquely efective |
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Term
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Definition
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Term
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Definition
| enhance seratogenic tone. : gi symtpoms, sexua ldysfunciton ,decreased libido, headache, insmomnia hyerpsomnia, weight gain, hyponatremia in elderly, increaased risk of bleeding, |
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Term
| teratogenic potential with waht drug |
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Definition
| paroxetine, and some ssris |
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Term
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Definition
| ssri efects plus noradrenergic effects such as increased bp, heart rate, adn cns acativation |
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Term
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Definition
| snri effects plus orthostatic hypotention, seadation, arrythmogenic, and anticholinergic |
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Term
| HCA, traozodone adverse effects |
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Definition
| sedation, gi disturbances, orthosattic hypostention |
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Term
| buproprionadverse efefcts |
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Definition
| agitation , insomnia, anroexia |
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Term
| mirtazapine adverse effects |
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Definition
| significantly sedating, incresaed appetite and weight gain |
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Term
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Definition
orhostatic hypotesion, weight gain, sex distrubacnes
Improtant: tyrmaine containg foods itneractions causeh ypertesive crisis.
serotinin syndrome in combination of ssri and snri |
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Term
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Definition
life threatening, characters yb ams, fevere tacycardia htn agitation t,remor ,myclonus heyprreflexia ,ataxia , incoordiantion diaphoresis, and shiverign ,adn gi symptoms.
dont give ssri/snri with amoi , or anytthig nawith maoi actiiy, or serotengeric drugs |
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Term
| children therapyeutic choice |
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Definition
| flouextine only 2nd gen drug aprpoved for chidlren. Concerned abaout suicidal risk, so now monitored when begin antidepressant |
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Term
| pharmacodynamic itneractions of antidepressants |
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Definition
| those sedative effects are additive to toher drugs such as benzodiapines nad alcohol, maois sensitize patients to indirect sympahtomiemtics . also serotoinin syndroem |
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Term
| pharmacokinetic effects of antidepressants |
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Definition
| paroxetine and fluoxetine potently inhibit cyp2d6, fluvoxamien and others inhbiit cyp3a4 |
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Term
| phamaconkinetic of antidepresants |
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Definition
| rapid oral abosrp, fast plasma concentration, metabolziedby liver and elimianted by kidney |
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Term
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Definition
| for bipolar affectiev disorder |
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Term
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Definition
| enters via sodium channels, may increase effects of seratonin, may decrese turn over of ne and DA. , may reduce synaptic trnasmission |
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Term
| ltihium drug interactions |
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Definition
| diurectics, decrease renal clearance, nsaids decrease clearance by increased li reabospriton. |
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Term
| overdosing on antidepressatnts |
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Definition
| extremley dangerous with TCAS, no refill basis |
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Term
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Definition
| excreted in urine completle, low access to itnracelluar comparmetn NO Protein binding |
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Term
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Definition
| tremor, inhibits potassium entry to myocytes, decresed thyroid function, polyuria |
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Term
| lithium contraidnciations |
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Definition
| dont give to patients lactating, with sodim deficits or dehyd, or signiciant cardio disease or renal impairtment |
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Definition
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