Term
|
Definition
| Noradrenergic and specific serotonergic; no effect on NT reuptake, 5HT and alpha 2 antagonist, no anti-cholinergic effects, antihistamine effect leads to somnolence |
|
|
Term
|
Definition
| No effect on reuptake of NT, no SSRI like effects (anorgasmia, nausea, diarrhea, insomnia), PRIAPISM, sleep-aid because antihistamine effects lead to somnolence |
|
|
Term
|
Definition
| Week neuronal uptake of NE, 5HT and DA |
|
|
Term
|
Definition
| Decreased glutamate release and modulation of voltage-gated calcium/sodium channels; Anticonvulsant; used with bipolar depression as well (w/o mania); SLOW titration and contraindicated in pregnancy (fast titration = SJ syndrome) |
|
|
Term
|
Definition
| Affects second messenger systems - recycling of PIP2, Wnt pathway and inhibits adenylyl cyclase; Euphoric mania and bipolar depression; suicide prevention; Renal failure, contraindicated in pregnancy due to Ebstein's anomaly in the fetus |
|
|
Term
|
Definition
| Kidneys almost entirely; inhibited by NSAIDs, thiazides, ACEI and Ca channel blockers |
|
|
Term
| Side effects/toxicity of lithium |
|
Definition
| Polyuria, polydipsia, nausea, slowed cardiac conduction, tremor/slowed cognition, acne/psoriasis/rash - LETHAL in overdose |
|
|
