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Antidepressants
Everything...(Cooperwood/Womble) Exam 2
32
Pharmacology
Professional
10/21/2010

Additional Pharmacology Flashcards

 


 

Cards

Term

 

 

 

 

Imipramine

Definition

Tofranil®

 

Mechanism of Action: Inhibits NE and 5HT reuptake in the presynaptic nerve terminal; antagonizes 5-HT (presynaptic), α-adrenergic, histamine and muscarinic receptors

 

Side Effects: Anticholinergic SE, aggravation of glaucoma and epilepsy, cardiac overstimulation, orthostatic hypoTN, sedation, manic behavior

 

Metabolism: Oxidation at 2 follow by glucuronidation

 

TCA

**Note: Used for bedwetting in kids**

Term

 

 

 

 

Desipramine

Definition

Norpramin®

 

Mechanism of Action: Inhibits NE and 5HT reuptake in the presynaptic nerve terminal; antagonizes 5-HT (presynaptic), α-adrenergic, histamine and muscarinic receptors

 

Side Effects: Anticholinergic SE, aggravation of glaucoma and epilepsy, cardiac overstimulation, orthostatic hypoTN, sedation, manic behavior

 

Metabolism: 2 –hydroxylation follow by gluc

 

TCA 

Term

 

 

 

 

Amitriptyline

Definition

Elavil®

 

Mechanism of Action: Inhibits NE and 5HT reuptake in the presynaptic nerve terminal; antagonizes 5-HT (presynaptic), α-adrenergic, histamine and muscarinic receptors

 

Side Effects: Anticholinergic SE, aggravation of glaucoma and epilepsy, cardiac overstimulation, orthostatic hypoTN, sedation, manic behavior

 

Metabolism: Hydroxylation at 1and 5 position followed by conjugation; N-demethylation

 

TCA

Term

 

 

 

 

 

Nortriptyline

 

Definition

Pamelor®, Aventyl®

 

Mechanism of Action: Inhibits NE and 5HT reuptake in the presynaptic nerve terminal; antagonizes 5-HT (presynaptic), α-adrenergic, histamine and muscarinic receptors

 

Side Effects: Anticholinergic SE, aggravation of glaucoma and epilepsy, cardiac overstimulation, orthostatic hypoTN, sedation, manic behavior

 

Metabolism:N-demethylation, 10-hydroxylation

 

TCA

Term

 

 

 

 

 

Protriptyline

Definition

Vivactyl®

 

Mechanism of Action: Inhibits NE and 5HT reuptake in the presynaptic nerve terminal; antagonizes 5-HT (presynaptic), α-adrenergic, histamine and muscarinic receptors

 

Side Effects: Anticholinergic SE, aggravation of glaucoma and epilepsy, cardiac overstimulation, orthostatic hypoTN, sedation, manic behavior

 

Metabolism: Not Specified

 

TCA

Term

 

 

 

 

 

Doxepin

Definition

Sinequan®

 

Mechanism of Action: Inhibits NE and 5HT reuptake in the presynaptic nerve terminal; antagonizes 5-HT (presynaptic), α-adrenergic, histamine and muscarinic receptors

 

Side Effects: Anticholinergic SE, aggravation of glaucoma and epilepsy, cardiac overstimulation, orthostatic hypoTN, sedation, manic behavior

 

Metabolism: Not specified

 

TCA

Term

 

 

 

 

 

Clomipramine

Definition

Anafranil®

 

Mechanism of Action: Inhibits NE and 5HT reuptake in the presynaptic nerve terminal; antagonizes 5-HT (presynaptic), α-adrenergic, histamine and muscarinic receptors

 

Side Effects: Anticholinergic SE, aggravation of glaucoma and epilepsy, cardiac overstimulation, orthostatic hypoTN, sedation, manic behavior

 

Metabolism: Not specified

 

TCA

Term

 

 

 

 

 

Trimipramine

Definition

Surmontil®

 

Mechanism of Action: Inhibits NE and 5HT reuptake in the presynaptic nerve terminal; antagonizes 5-HT (presynaptic), α-adrenergic, histamine and muscarinic receptors

 

Side Effects: Anticholinergic SE, aggravation of glaucoma and epilepsy, cardiac overstimulation, orthostatic hypoTN, sedation, manic behavior

 

Metabolism: Not specified

 

TCA

Term

 

 

 

 

Trazodone

Definition

 

 

 

Desyrel®

 

Metabolism: N-Dealkylation to m-chloropiperazine active metabolite

 

5HT-2 Antagonist

Term

 

 

 

 

Nefazodone

Definition

 

 

 

Serzone®

 

Metabolism: Not specified

 

5HT-2 Antagonist

Term

 

 

 

 

Isocarboxazid

Definition

Marplan®

 

Mechanism of Action: Inhibits MAO and causes accumulation of 5-HT, NE, & DA in CNS and periphery

 

SE: CNS stimulation, restlessness, anxiety, tremors, othostatic hypotension

 

Metabolism: Not specified

 

MAOI (Irreversible MAOa inhibitor)

**Note: Avoid tyramine containing foods (Beer, wine, cheese, chicken liver, avacodos, chocolate, bananas)**

Term

 

 

 

 

Phenelzine

Definition

Nardil®

 

Mechanism of Action: Inhibits MAO and causes accumulation of 5-HT, NE, & DA in CNS and periphery

 

SE: CNS stimulation, restlessness, anxiety, tremors, othostatic hypotension

 

Metabolism: Not specified

 

MAOI (Irreversible MAOa inhibitor)

**Note: Avoid tyramine containing foods (Beer, wine, cheese, chicken liver, avacodos, chocolate, bananas)**

Term

 

 

 

 

Tranylcypromine

Definition

Parnate®

 

Mechanism of Action: Inhibits MAO and causes accumulation of 5-HT, NE, & DA in CNS and periphery

 

SE: CNS stimulation, restlessness, anxiety, tremors, othostatic hypotension

 

Metabolism: Not specified

 

MAOI (Reversible MAOb inhibitor)

**Note: Avoid tyramine containing foods (Beer, wine, cheese, chicken liver, avacodos, chocolate, bananas)**

Term

 

 

 

 

Selegiline

Definition

Deprenyl®

 

Mechanism of Action: Inhibits MAO and causes accumulation of 5-HT, NE, & DA in CNS and periphery

 

SE: CNS stimulation, restlessness, anxiety, tremors, othostatic hypotension

 

Metabolism: Not specified

 

MAOI (Reversible MAOb inhibitor)

**Note: Avoid tyramine containing foods (Beer, wine, cheese, chicken liver, avacodos, chocolate, bananas)**

Term

 

 

 

 

Moclobemide

Definition

Not available in US

 

Mechanism of Action: Inhibits MAO and causes accumulation of 5-HT, NE, & DA in CNS and periphery

 

SE: CNS stimulation, restlessness, anxiety, tremors, othostatic hypotension

 

Metabolism: Not specified

 

MAOI (Reversible MAOa inhibitor)

**Note: Avoid tyramine containing foods (Beer, wine, cheese, chicken liver, avacodos, chocolate, bananas)**

Term

 

 

 

 

Fluoxetine

Definition

Prozac®

 

Use: Mental depression, OCD, bulemia

 

Mechanism of Action: Selectively inhibits serotonin reuptake

 

SE: Nausea, decreased libido, anorexia, anxiety, insomnia, tremors, sleepiness, sweating

 

Metabolism: Not specified

 

SSRI

Term

 

 

 

 

Citalopram

Definition

Celexa®

 

Use: Mental depression

 

Mechanism of Action: Selectively inhibits serotonin reuptake

 

SE: Nausea, decreased libido, anorexia, anxiety, insomnia, tremors, sleepiness, sweating

 

Metabolism: Not specified

 

SSRI

Term

 

 

 

 

Fluvoxamine

Definition

Luvox®

 

Use: OCD

 

Mechanism of Action: Selectively inhibits serotonin reuptake

 

SE: Nausea, decreased libido, anorexia, anxiety, insomnia, tremors, sleepiness, sweating

 

Metabolism: Not specified

 

SSRI

Term

 

 

 

 

Paroxetine

Definition

Paxil®

 

Use: Mental depression, panic disorder, OCD

 

Mechanism of Action: Selectively inhibits serotonin reuptake

 

SE: Nausea, decreased libido, anorexia, anxiety, insomnia, tremors, sleepiness, sweating

 

Metabolism: Formation of catecholamine followed by gluc.

 

SSRI

Term

 

 

 

 

Sertraline

Definition

Zoloft®

 

Use: Mental depression

 

Mechanism of Action: Selectively inhibits serotonin reuptake

 

SE: Nausea, decreased libido, anorexia, anxiety, insomnia, tremors, sleepiness, sweating

 

Metabolism: N-demethylation

 

SSRI

Term

 

 

 

 

Escitalopram

Definition

Lexapro®

 

Mechanism of Action: Selectively inhibits serotonin reuptake

 

SE: Nausea, decreased libido, anorexia, anxiety, insomnia, tremors, sleepiness, sweating

 

Metabolism: N-demethylation to active metabolite

 

SSRI

Term

 

 

 

 

Duloxetine

Definition

 

 

 

Cymbalta®

 

Metabolism: Not specified

 

SNRI

Term

 

 

 

 

Venlafaxine

Definition

 

 

 

Effexor®

 

Metabolism: O-demethylation to active metabolite

 

SNRI

Term

 

 

 

 

Desvenlafaxine

Definition

 

 

 

Pristiq®

 

Metabolism: Not specified

 

SNRI

Term

 

 

 

 

Bupropion

Definition

 

 

 

Wellbutrin®

 

Metabolism: Not specified

 

Tetracyclics and Unicyclics

Term

 

 

 

 

Amoxapine

Definition

 

 

 

Asendin®

 

Metabolism: Not Specified (Active metabolite of Loxapine)

 

Tetracyclics and Unicyclics (Dibenzoxapin)

Term

 

 

 

 

Maprotiline

Definition

 

 

 

Ludiomil®

 

Metabolism: N-demethylation to active metabolite

 

Tetracyclic and Unicyclics

Term

 

 

 

 

Mirtazapine

Definition

 

 

 

Remeron®

 

Metabolism: N-demethylation and hydroxylation of pyridine

 

Tetracyclics and Unicyclics (Alpha-2 and 5HT antagonist)

Term

 

 

 

 

Buspirone

Definition

 

 

 

Buspar®

 

Metabolism: Not specified

 

Partial 5-HT 1a agonist

Term

 

 

 

 

Reboxetine

Definition

 

 

 

Vestra®

 

Metabolism: Not specified

 

NE Reuptake inhibitor (Not sure, but structures are similar; Not Available in US)

Term

 

 

 

 

Atomoxetine

Definition

 

 

 

Strattera®

 

Metabolism: N-demethylation another route p-hydroxylation followed by gluc

 

NE Reuptake Inhibitor

Term

 

 

 

 

Nisoxetine

Definition

 

 

 

Not available in US

 

Metabolism: Not specified

 

NE Reuptake Inhibitor

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