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Antidepressants
Test 3
21
Pharmacology
Professional
03/21/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
Tranycypromine
Definition

Anti-depressant

MAOI

Term
MAO-A
Definition
breaksdown 5-HT and NE
Term
MAO-B
Definition
-breaks down Dopamine (inhibitors have little effect of depression)
Term
MAOi
Definition

- irreversibly inhibits MAO-A and B

Sfx: Hypertensive Crisis- sympathetic activation (wine and cheese)

Serotonin Syndrome-hyperreflexia, dilated pupils, rhabdomyolysis, met acidosis, shivering

*Increase risk of suicide

Term
Tricyclic Antidepressants
Definition

-Prevent reuptake of serotonin and NE

-inhibits activation of muscarinic receptors

Sfx: weight gain, prolongs QT interval, suicide (OD)

Term
Amitryptiline
Definition

Tertiary-amine TCA (antidepressant)

-more effective at blocking reuptake of serotonin than NE

Term
Imiprimine
Definition

Tertiary-amine TCA (antidepressant)

-more effective at blocking reuptake of serotonin than NE

Term
Nortriptyline
Definition

Secondary-amine TCA

-more effective at blocking reuptake of NE

-Less anticholinergic Sfx

Term
Desiprimine
Definition

Secondary-amine TCA

-more effective at blocking reuptake of NE

-Less anticholinergic Sfx

Term
Serotonin Selective Reuptake Inhibitors (SSRI)
Definition

Once a day dosing

Inhibitors of P450 (esp Paroxetine and Fluoxetine)

Sfx: may precipitate mania, Serotonin Syndrome, ^ suicide

Term
Escitalopram
Definition
SSRI
Term
Fluoxetine
Definition

SSRI

P450 inhibitor

Term
Paroxetine
Definition

SSRI

P450 inhibitor

Term
Sertraline
Definition
SSRI
Term
Serotonin-Norepinephrine Reuptake Inhibitor (SNRIs)
Definition
Not P450 blockers
Term
Venlafaxine
Definition

SNRI (antidepressant)

-better at blocking reuptake of Serotonin

-weak action at Dopamine reuptake

Major metabolite desvenlafaxine, is also approved for depression

Term
Duloxetine
Definition

SNRI

-equally effective at inhibiting reuptake of 5-HT and NE

Term
Buproprion
Definition

Atypical antidepressant

-Decrease craving for nicotine
Not good for someone with epilepsy (lowers seizure threshold)
-less likely to cause sexual dysfunction

Term
Mirtazapine
Definition

Atypical Anti-depressant

-blocks pre-synaptic a2-adrenergic autoreceptors (^NE)

-Antagonis at 5-HT2 and 3

Sfx: ^appetite and weight gain (good for wasting syndrome)

*antiemisis and antipruritic actions

Term
Trazodone
Definition

Atypical anti-depressant

-weak inhibitor of 5-HT reuptake

-Antag @ 5-HT1 presynaptic autoreceptors= ^ seroton

-Antag @ 5-HT2

*good for insomnia too

Term
Lithium
Definition

Mood stabilizer (Anti-Bipolar)

*high sodium promotes excretion

Need to check thyroid fxn

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