Term
| Monoamine Hypothesis Depression |
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Definition
depression caused by a decrease in 5ht and/or adrenergic and/or dopamine in CNS
may be simplified because takes several weeeks to correct with drugs (neuroplasticity?) |
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Term
| Augmentation in Antidepressants |
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Definition
Instead of switching drugs in the same class (as per usual) a second drug is utilized
example: thyroid hormone, folate, lithium |
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Term
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Definition
SSRI Antidepressant and anti-anxiety
Better at negative than positive affect
SERT Transporter plus others
BDNF for dendritic arborization
NO CYP INTERACTION
Down Libido, Anti-platelet, GI upset
Pre-eclamsia balanced by suicide prevention pregnancy
increases QT interval |
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Term
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Definition
SSRI Antidepressant and anti-anxiety
better at negative than positive affect
SERT Transporter plus NRI plus 5HT2C
BDNF for dendritic arborization
Cyp2D6 interactions
NO WITHDRAWL DUE TO LONG HALFLIFE
Down Libido, Anti-platelet, GI upset, INSOMNIA
Pre-eclamsia balanced by suicide prevention pregnancy |
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Term
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Definition
SSRI Antidepressant and anti-anxiety
better at negative than positive affect
SERT Transporter plus DRI
BDNF for dendritic arborization
DRI --> desirable for hypersonia
CONTRAINDICATED INSOMNIA
WORST CYP450 Interaction
Down Libido, Anti-platelet, GI upset, INSOMNIA
Pre-eclamsia balanced by suicide prevention pregnancy |
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Term
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Definition
SNRI
NRI causes INCREASED DOPAMINE PREFRONTAL CORTEX (not alot of dat)
Also approved for Neuropathic pain!
INCREASES POSITIVE AFFECT
Sexual dysfunction, GI upset, Withdrawl symptoms, hypertension
(less than venlafaxine) |
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Term
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Definition
SNRI (@ low dose acts like SSRI)
NRI causes INCREASED DOPAMINE PREFRONTAL CORTEX (not alot of dat)
INCREASES POSITIVE AFFECT
Sexual dysfunction, GI upset, Withdrawl symptoms, hypertension
(more than duloxitine) |
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Term
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Definition
Atypical antidepressant
NRI/DRI utilized because no 5HT
Positive affect and broadens ssri effects
CONTRAINDICATED SIEZURES |
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Term
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Definition
Atypical antidepressant
A2, H1, 5HT2C,
Blocks A2 (inhibitory receptor):Increases 5HT/N
Blocks H1: increased appetite, sedate
little SERT: decreased SSRI effects
Blocks 5HT1: anti-anxiety and reduced sexual side effects
MOST WEIGHT GAIN |
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Term
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Definition
Tricyclic anti-depressant and neuropath
SRI, NRI, Na transporter
A1, H1, M1 blockers
OVERDOSE: Seizures, coma, arrythmia
(can give limited # pills prescript)
CYP2D6 INHIBITION
sedation, dry mouth and poor vision, orthostatic hypotension, cardiotoxic |
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Term
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Definition
Tricyclic anti-depressant and neuropath
SRI, NRI, Na transporter
A1, H1, M1 blockers
OVERDOSE: Seizures, coma, arrythmia
(can give limited # pills prescript)
sedation, dry mouth and poor vision, orthostatic hypotension, cardiotoxic |
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Term
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Definition
Excess Serotonin either by reuptake inhibition of 5HT activation leads to
1. Tachycardia, hypertension
2. anxiousness
3. Tremor/hyperreflexia
4. Tonic Clonic convulsions |
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