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Anticonvulsants
Terry
16
Medical
Professional
11/15/2009

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Term
Phenobarbitol
Definition

Phenobarbitol

Anticonvulsants.

generalized tonic-clonic seizure.

enhances GABA, depress Ca channel.

drowsiness, induces hepatics.

Term
Phenytoin
Definition

Phenytoin

Anticonvulsants.

generalized and partial seizures.

NOT for absence seizures.

decreases Na, Ca, K flow.

GINGIVAL hyperplasia, Folate, Peripheral neuropathy, masculinization.

Term
Carbamazepine
Definition

Carbamazepine

Anticonvulsants.

for partial, generalized tonic-clonic, trigeminal neuralgia.

prolonged recovery of Na channels.

N&V, diplopia, hematologic/thrombocytopenia.

Term
Valproate/Divalproex
Definition

Valproate/Divalproex

Anticonvulsants.

can treat ABSENCE.

Na and GABA

weight gain, hair loss, liver

Term
Ethosuximide
Definition

Ethosuximide

Anticonvulsants.

Absence Seizures.

Block Ca channel, decreased glucose transport. drowsiness.

Term
Benzodiazepines
Definition

Benzodiazepines

Anticonvulsants.

 

diazepam and lorazapam (status, EtOH withdrawl). clonazepam (akinetic, myoclonic, Lennox-Gastaut)

 

enhanced GABA binding.

abuse potential, tolerance.

Term
Felbamate
Definition

Felbamate

Anticonvulsants.

adjunct for complex partial, lennox-gastaut.

NMDA antagonist.

aplastic anemia, hepatotoxic.

NOT a first line.

Term
Lamotrigine
Definition

Lamotrigine

Anticonvulsants.

used for complex partial.

inhibits Na channels.

Steven's Johnson.

Term
Gabapentin
Definition

Gabapentin

Anticonvulsants.

adjunct for complex partial.

MOA-everything.

also: bipolar, chronic pain, peripheral neuropathy.

eliminated in KIDNEYS.

Term
Pregabalin
Definition

Pregabalin

Anticonvulsants.

adjunct complex partial.

Ca channel.

tx: POSTHERPETIC NEURALGIA.

Term
Topiramate
Definition

Topiramate

Anticonvulsants.

complex partial, GTCS, Lennox Gastaut.

 

inhibits Na, enhances GABA.

 

drink plenty of FLUIDS (kidney stones).

 

used in migraines

Term
Tiagibine
Definition

Tiagibine

Anticonvulsants.

Adjunct complex-partial.

inhibits GABA reuptake (GAT-1).

Term
Levetiracetam
Definition

Levetiracetam

Anticonvulsants.

adjunct complex partial.

binds synaptic vesicular protein SV2A.

Asthenia

Term
Zonisamide
Definition

Zonisamide

Anticonvulsants.

adjunct complex-partial.

inhibits Na and Ca.

kidney stones.

Term
Lacosamide
Definition

Lacosamide

Anticonvulsants.

adjunct complex-partial.

enhances slow activation Na channels.

euphoria (controlled substance).

cardiac s/e.

Term
Rufinamide
Definition

Rufinamide

Anticonvulsants.

adjunct for lennox gastaut in patients >4 yo. prolonged inactivation Na channel

cardiac s/e

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