Term
| What Factor has the shortest 1/2 life? |
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Definition
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Term
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Definition
IV, SubQ
Unfractionated
LMWH
Binds antithrombin III inactivates Factors Xa, XIa, XIIa |
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Term
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Definition
IV-loading dose is 70-100
Maintenance dose: 18
check aPTT, check levels every 6 hours
Monitor CBC, platelets
Look for signs of bleeding |
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Term
| Adverse effects of Heparin |
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Definition
Hemorrhage
Thrombocytopenia
Paradoxical thrombosis |
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Term
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Definition
Protamine- resists anti-coagulation
Whole blood
Fresh frozen plasma, give this unless major bleed |
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Term
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Definition
DVT and PT Tx
don't monitor PTT
Anti-factor X assay (people at risk for bleeding)
Factor X specific
Less chance of HIT |
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Term
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Definition
end in -parin
Enoxa
Dalte
Arde
Tinza |
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Term
|
Definition
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Term
| If person has SE of heparin use? |
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Definition
Fondaparinux-a heparinoid
Contraindicated of CRCl < 30 |
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Term
| Direct Thrombin Inhibitors |
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Definition
| Binds to unique sites on thrombi |
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Term
Direct Thrombin Inhibitors: Divalent
Binds to 2 sites |
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Definition
Hirudin
Lepirudin, IV, continuous infusion, aPTT
Bivalirudin, IV, continuous infusion, aPTT |
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Term
Direct Thrombin Inhibitors: Univalent
Binds to 1 site |
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Definition
Argatroban, IV
Dabigatran, PO |
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Term
|
Definition
Aternative to heparin
Works in presence of HIT
Less monitoring |
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Term
|
Definition
Quick onset
Short 1/2 life
Used for angioplasty |
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Term
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Definition
| Used in patients with HIT |
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Term
|
Definition
Antagonizes vitamin K
Depletes factors II, VII, IX, X, protein C and protein S
Onset of action: 1-2days
Anticoag: 2-7 days, avg 5 |
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Term
|
Definition
Well absorbed
Highly protein bound= increased chance of drug interactions = increased chance of bleeding
Metabolized by liver |
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Term
|
Definition
check INR and PT
No loading dose
No pregnant women |
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Term
|
Definition
Start one day after heparin
A therapeutic PT doesn't mean true anticoagulation |
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Term
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Definition
Bleeding
Thrombocytopenia- less likely than heparin |
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Term
| Warfarin + enzyme inducers |
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Definition
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Term
| Warfarin + enzyme inhibitors or protein displacement |
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Definition
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Term
| Warfarin Adverse Interactions |
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Definition
Vit K containing foods
Antacids
Smoking |
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Term
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Definition
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Term
| Pre-Procedural Management |
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Definition
Stop warfarin 5-7 days prior to procedure
Start enoxaparin at treatment dose
Last dose of enoxaparin 24 hours prior to procedure
Restart enoxaparin and warfarin the evening following the procedure and continue till INR is therapeutic and then stop enoxaprin |
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Term
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Definition
Inihibit ADP-dependent activation of GP IIb/III a complex
Used for ACS, stroke prevention, and post-stroke
End in -grel |
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Term
|
Definition
MI and stroke, must start as soon as diagnosis is made
Act on plasminogen to form plasmin, dissolves clots
end in -plase |
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