digoxin (lanoxin) *know structure to name*

cardiac glycoside

competitive Na+/K+ ATPase

oral

inamrinone (Inocor)

positive ionotropic agent

inodilators

phosphodiesterase III inhibitor

injection

milrinone (primacor)

positive inotrophic agent

inodilators

phosphodiesterase III inhibitor

injection

warfarin (Coumadin) *know structure to name*

vitamin K antagonist

Oral anticoagulant

How do you treat overdose?

Inhibits what 2 enxymes?

safe in pregnancy?

brodifacoum

superwarfarin rodenticide

vitamin K antagonist

oral anticoagulant

very long halflife

chlorophacinone

superwarfarin rodenticide

vitamin K antagonist

oral anticoagulant

very long halflife

vitamin K₁ (mephyton)

vitamin K agonist

coagulant

Vitamin K₂

vitamin K agonist

coagulant

Menadiol sodium diphosphate (synkavite)

(vitamin K₄)

vitamin K agonist

coagulant

(vit K4)

prodrug

Vitamin K₃

vitamin K agonist

coagulant

Heparin

injectable anticoagulant

safe in pregnancy?

Protamine sulfate

treatment for heparin overdose

heparin antagonist

coagulant

Fondaparinus sodium (Arixtra)

factor Xa specific inhibitor

injectable anticoagulant

rivaroxiban (Xarelto)

factor Xa specific inhibitor

oral anticoagulant

Apixaban (Eliquis)

factor Xa specific inhibitor

oral anticoagulant

LMWH

factor Xa

specific inhibitor

injectible anticoagulant

Edoxaban (Savaysa)

factor Xa specific inhibitor

oral anticoagulant

direct thrombin inhibitor

irreversible bivalent DTI

injectable anticoagulant

antiplatelet agent

direct thrombin inhibitor

reversible bivalent DTI

injectable anticoagulant

antiplatelet agent

Argatroban (Novastan)

direct thrombin inhibitor

reversible univalent DTI

injectable anticoagulant

Antiplatelet agent

dabigatran etexilate (Pradaxa)

direct thrombin inhibitor

reversible univalent DTI

oral anticoagulant

prodrug (can you draw active?)

antiplatelet agent

aspirin

antiplatelet inhibitor

irreversible COX inhibitor 

oral

dipyridamole

antiplatelet inhibitor

phosphodiesterase 3 inhibitor

oral

cilostazol (Pletal)

antiplatelet inhibitor

phosphodiesterase 3 inhibitor

(adenosine reuptake inhibitor as well)

oral

Ticlopidine (Ticlid)

antiplatelet inhibitor

P2Y12 purinergic receptor antagonist

irreversible

prodrug

oral

clopidogrel (Plavix)

antiplatelet inhibitor

P2Y12 purinergic receptor antagonist

irreversible

prodrug

oral

[image]

Prasugrel (Effient)

antiplatelet inhibitor

P2Y12 purinergic receptor antagonist

irreversible

prodrug

oral

Ticragrelor (Brilinta)

antiplatelet inhibitor

P2Y12 purinergic receptor antagonist

Reversible noncompetitive (with ADP)

oral

Vorapaxar (Zontivity)

antiplatelet inhibitor

PAR-1 antagonist

oral

Eptifibatide

antiplatelet inhibitor

GP IIb/IIIa receptor antagonist

IV

Tirofiban (Aggrastat)

antiplatelet inhibitor

GP IIb/IIIa receptor antagonist

IV

thrombolytic enzymes

tissue plasmogen activators (tPA)

injection

thrombolytic enzyme

(degrades fibrin and fibrinogen directly)

injection

antihistamine

H1 receptor, sedating

Ethanolamine

Antihistamine

H1 receptor, sedating

Ethanolamine

Antihistamine

H1 receptor, sedating

Ethanolamine

Antihistamine

H1 receptor, sedating

Ethanolamine

Antihistamine

H1 receptor, sedating

Ethanolamine

Antihistamine

H1 receptor, sedating

Ethanolamine

Antihistamine

H1 receptor, sedating

Ethylenediamine

Pyrilamine

Antihistamine

H1 receptor, sedating

Ethylenediamine

Tripelennamine

Antihistamine

H1 receptor, sedating

Ethylenediamine

Chlorpheniramine

Antihistamine

H1 receptor, sedating

Propylamine

pheniramine

Antihistamine

H1 receptor, sedating

Propylamine

brompheniramine

Antihistamine

H1 receptor, sedating

Propylamine

phenindamine

Antihistamine

H1 receptor, sedating

Propylamine

triprolidine

Antihistamine

H1 receptor, sedating

Propylamine

Acrivastine

Antihistamine

H1 receptor, NONSEDATING

Propylamine

methdilazine

Antihistamine

H1 receptor, sedating

phenothiazine

Promethazine

Antihistamine

H1 receptor, sedating

phenothiazine

trimeprazine

Antihistamine

H1 receptor, sedating

phenothiazine

loratadine

Antihistamine

H1 receptor, NONSEDATING

piperidine

cyproheptadine

Antihistamine

H1 receptor, sedating

piperidine

Antihistamine

H1 receptor, sedating

piperidine

desloratidine

Antihistamine

H1 receptor, NONSEDATING

piperidine

cyclizine

Antihistamine

H1 receptor, sedating

piperazine

meclizine

Antihistamine

H1 receptor, sedating

piperazine

astemizole

Antihistamine

H1 receptor

NONSEDATING

piperidine

(withdrawn, cardiac arrhythmias)

cetirizine

Antihistamine

H1 receptor

NONSEDATING

piperazine

hydroxizine

Antihistamine

H1 receptor, sedating

piperazine

mizolastine

Antihistamine

H1 receptor

NONSEDATING

piperidine

(Europe)

Terfinadine

Antihistamine

H1 receptor

piperidine

(withdrawn, cardiac arrhythmias)

fexofinadine

Antihistamine

H1 receptor

NONSEDATING

piperidine

Inhibit Histamine Release

Mast Cell Degranulation Inhibitor

Inhibit Histamine Release

Mast Cell Degranulation Inhibitor

Inhibit Histamine Release

Mast Cell Degranulation Inhibitor

Inhibit Histamine Release

Mast Cell Degranulation Inhibitor

androgen

testosterone

(draw it)

Progestin

progesterone

(draw it)

Cholesterol

(precursor to steroid hormones)

Estrogen

Estradiol

(draw it)

Mineralocorticoid

Aldosterone

(draw it)

glucocorticoid

Cortisol

(draw it)

estradiol metabolite

agonist

Estrogen Agonist

Estriol (E3)

Estrogen Agonist

Estrone (E1)

Conjugated Estrogen Metabolite Agonist

oral, prodrug

Estradiol Metabolite Agonist

prodrug

Estradiol Metabolite Agonist

prodrug

conjugated Estrogen Metabolite Agonist

oral, prodrug

estradiol metabolite agonist

(prodrug)

estradiol metabolite agonist

prodrug

synthetic estrogen agonist

IM, prodrug, long DOA

conjugated estrogen metabolite agonist

oral, prodrug

conjugated estrogen metabolite agonist

oral, prodrug

Synthetic estrogen agonist

oral, prodrug

ethinyl estradiol *know structure to name*

synthetic estrogen agonist

oral

Main componenet of birth control pills

Synthetic estrogen agonist

IM, prodrug, long DOA

Phytoestrogen

Estrogen agonist

oral

synthetic estrogen agonist

oral prodrug

SERM/ Antiestrogen / estrogen antagonist

mixed agonist/antagonist

nonsteroidal, prodrug

oral

Use:  chemo - prevention and treatment of breast cancer

phytoestrogen

estrogen agonist

oral

phytoestrogen

estrogen agonist

oral

fulvestrant (Faslodex) *know structure to name*

antiestrogen/estrogen antagonist

pure antagonist

steroidal

IM

clomiphene (Clomid)

antiestrogen / ER antagonist

mixed agonist/antagonist

nonsteroidal prodrug

oral

use:  induces ovulation

tamoxifen (Nolvadex) *know structure to name*

antiestrogen/estrogen antagonist

mixed agonist / antagonist

nonsteroidal, prodrug

oral

Use:  breast cancer

irreversible steroidal aromatase inhibitor

oral

acolbifene

antiestrogen

pure estrogen antagonist

prodrug

raloxifene (Evista) *know structure to name*

SERM or antiestrogen

estrogen antagonist

oral

use:  osteoporosis & chemoprevention of breast cancer in women with osteoporosis

Anastrozole (Arimidex) *know structure to name* competitive nonsteroidal aromatase inhibitor

oral

letrozole (Femara) *know structure to name*

competitive nonsteroidal aromatase inhibitor

oral

bazedoxifene (Duavee)

SERM/antiestrogen

mixed estrogen agonist/antagonist

nonsteroidal

oral

Use:  prevention of osteoporosis

treatment of menopausal symptoms in combo w/ conjugated estrogen

ospemifene (Osphena)

SERM / antiestrogen

mixed estrogen agonist/antagonist

nonsteroidal, prodrug

oral