• Inhibit Thromboxane synthesis

(Cox1 inhibitor)

• Inhibits phosphodiesterase
• ↑cAMP
• ↓ TXA2 production.
• Blocks platelet adhesion to vessels

• Inhibit ADP binding to platelet receptor (irreversible)

• Binds Antithrombin III, ↑ activity

• (+) neutralizes (-) Heparin

• Blocks vitamin K
• Inhibit synthesis of factors & anticoagulent proteins.

• Binds & blocks thrombin
• for patients with heparin induced thrombocytopenia.

• Binds and activates plasminogen
• (Antigenic)

• Binds and activates plasminogen
• (non-antigenic)

• causes plasminogen to have greater affinity for fibrin.

• competatively inhibits plasminogen activation
• counters fibrinolysis

• Hemophilia A

• Hemophilia B

• Counter Coumadin
• Newborn hemorrhagic disease