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Anticoagulants
Exam 2
14
Pharmacology
Professional
01/07/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Aspirin
Definition
  • Inhibit Thromboxane synthesis

(Cox1 inhibitor)

Term
Dipyridamole
Definition
  • Inhibits phosphodiesterase
  • ↑cAMP
  • ↓ TXA2 production.
  • Blocks platelet adhesion to vessels
Term
Clopidrogel (Plavix)
Definition
  • Inhibit ADP binding to platelet receptor (irreversible)
Term
Heparin
Definition
  • Binds Antithrombin III, ↑ activity
Term
Protamine Sulfate
Definition
  • (+) neutralizes (-) Heparin
Term
Warfarin
Definition
  • Blocks vitamin K
  • Inhibit synthesis of factors & anticoagulent proteins.
Term
Lepirudin (Refludan)
Definition
  • Binds & blocks thrombin
  • for patients with heparin induced thrombocytopenia.
Term
Streptokinase
Definition
  • Binds and activates plasminogen
  • (Antigenic)
Term
Urokinase
Definition
  • Binds and activates plasminogen
  • (non-antigenic)
Term
Alteplase
Definition
  • causes plasminogen to have greater affinity for fibrin.
Term
Aminocaproic acid
Definition
  • competatively inhibits plasminogen activation
  • counters fibrinolysis
Term
Factot 8 (Hemofil)
Definition
  • Hemophilia A
Term
Factor 9 (Konyne)
Definition
  • Hemophilia B
Term
Phytonadione (Aquamephyton) (vitamin K)
Definition
  • Counter Coumadin
  • Newborn hemorrhagic disease
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