Term
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Definition
| Increases affinity of Antithrombin for Xa, increasing factor Xa and IIa inactivation. Reduces additional clot formation. Side effects include osteoporosis, bleeding, and heparin induced thrombocytopenia. Protamine reverses effects. |
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Term
| Enoxaprin, Dalteparin, Tinzaparin |
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Definition
| low molecular weight heparins. Fewer side effects, more expensive |
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Term
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Definition
| synthetic heparin analog. Only inactivates Factor Xa |
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Term
| Lepirudin, Bivalirudin, Desirudin, Argatroban |
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Definition
| Binds to and directly inhibits free thrombin. Leads to less fibrin clot formation |
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Term
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Definition
| Vitamin K analog. Blocks the synthesis of factors II, VII, IX, X, Protein C, and S. takes approximately 24 hours to take affect, with VII being the first reduced. |
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Term
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Definition
| P450 metabolized prodrug. Direct thrombin inhibitor. |
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Term
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Definition
| Factor X inhibitor used for the prevention of DVT |
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Term
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Definition
| COX inhibitor. inhibits thromboxane A2 formation, thus inhibiting platelet activation and aggregation |
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Term
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Definition
| phosphodiesterase inhibitor. inhibits the breakdown of cAMP, raising cAMP levels, reducing Ca levels, and reducing Platelet activation |
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Term
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Definition
| phosphodiesterase inhibitor, inhibts breakdown of cAMP, reducing Ca and platelet activation |
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Term
| Ticlopidine, Clopidogrel, Prasugrel |
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Definition
| ADP inhibitors, blocking platelet aggregation |
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Term
| abciximab, tirofiban, eptifibatide |
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Definition
| GPIIb/IIIa inhibitors, block platelet aggregation |
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Term
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Definition
| directly reduces platelet count by decreasing platelet formation. Takes approximately 1 to 2 weeks to take affect. |
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Term
| streptokinase, urokinase, TPA |
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Definition
| plasminogen activators. Plasmin dissolves preformed clot |
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Term
| aminocaproic acid, tranexamic acid |
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Definition
| inhibits plasminogen activator. no plasmin formation. no clot lysis. promotes clots |
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Term
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Definition
| mixed effect, increases plasminogen and decreases antithrombin |
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