Term
| WHAT IS THE REVERSAL FOR HEPARIN? |
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Definition
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Term
| PROTAMINE IS A STRONG BASE THAT FORMS WHAT TYPE OF BOND WITH HEPARIN? HOW DOES THAT WORK? |
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Definition
| IONIC BOND. THE POSITIVE CHARGE OF PROTAMINE COMBINES WITH THE NEGATIVE CHARGE OF HEPARIN |
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Term
| HOW IS PROTAMINE REMOVED? |
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Definition
| RAPIDLY REMOVED BY THE RETICULENDOTHELIAL SYSTEM (SPLEEN). CLEARANCE IS MORE RAPID THAN HEPARIN (CAN HAVE HEPARIN REBOUND). |
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Term
| WHAT IS THE DOSE OF PROTAMINE? |
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Definition
| 1MG OF PROTAMINE FOR EVERY 100 UNITS OF CIRCULATING HEPARIN. DOSE MAY BE DECREASED APPROX. 50% AFTER 1 HR, AND 75% AFTER 2 HRS FROM TIME OF HEPARIN ADMINISTRATION |
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Term
| WHAT IS THE ONSET OF PROTAMINE? |
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Definition
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Term
| WHAT ARE 3 SIDE EFFECTS OF PROTAMINE? |
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Definition
| HYPOTENSION, ALLERGIC REACTIONS, AND PULMONARY HTN |
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Term
| PROTAMINE CAUSES HYPOTENSION R/T HISTAMINE RELEASE. WHAT 3 SYMPTOMS DOES THAT CAUSE? |
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Definition
| HYPOTENSION, FLUSHING, AND TACHYCARDIA |
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Term
| HYPOTENSION WITH PROTAMINE IS MORE COMMON WITH WHAT? |
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Definition
| RAPID INJECTION AND IN PATIENTS WITH POOR LV FUNCTION. MAY BE MORE PROFOUND IF ADMINISTERED VIA CENTRAL LINE. R/T PULMONARY INACTIVATION CAUSING HISTAMINE RELEASE. LESS LIKELY IF ADMINISTERED THRU PERIPHERAL LINE. MORE TIME TO CIRCULATE PRIOR TO ENTERING PULMONARY CIRCULATION. |
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Term
| WITH PROTAMINE CAN PREVIOUS EXPOSURE TO HEPARIN CAUSE FORMATION OF ANTIBODIES? |
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Definition
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Term
| WHAT ARE 4 RISK FACTORS FOR ALLERGIC REACTIONS WITH PROTAMINE? |
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Definition
| DIABETICS (NPH P= PROTAMINE), PATIENTS WITH PREVIOUS EXPOSURE, VASECTOMY, FISH ALLERGIES (MADE FROM SALMON SPERM) |
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Term
| WHAT ARE THE 4 TREATMENTS OF ALLERGIC REACTION TO PROTAMINE? |
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Definition
| VASOPRESSORS (EPI START EARLY AND BE AGGRESSIVE, FLUID, STEROIDS, ANTIHISTAMINE |
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Term
| CAN PROTAMINE BY ITSELF HAVE AN ANTICOAGULANT EFFECT? EXPLAIN. |
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Definition
| YES. ONLY USEFUL WHEN GIVEN FOR HEPARIN INDUCED ANTICOAGULATION AS PROCOAGULANT. |
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Term
| LMWH IS DERIVED FROM STANDARD UNFRACTIONATED HEPARIN AND ABOUT __ THE MOLECULAR WEIGHT AND SIZE OF UFH. |
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Definition
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Term
| LMWH IS APPROX. 3 TIMES MORE SELECTIVE FOR INHIBITING FACTOR ___ OVER ___ THAN UFH. |
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Definition
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Term
| WHAT IS THE REVERSAL FOR LMWH? |
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Definition
| IN EMERGENCY, PROTAMIN MAY BE USED AS REVERSAL, BUT ONLY NEUTRALIZES ABOUT 65% OF LMWH'S ACTIVITY |
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Term
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Definition
| ENOXAPARIN (LOVENOX), DALTEPARIN (FRAGMIN), AND TINZAPARIN (INNOHEP) |
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Term
| FOR ANESTHESIA IMPLICATIONS WHEN SHOULD THE LAST DOSE OF LMWH BE GIVEN. |
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Definition
| AT LEAST 12 HRS BEFORE SURGERY |
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Term
| WHAT IS A CONTRAINDICATION WITH LMWH THERAPY? |
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Definition
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