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Anticoagulants
Part 2
18
Nursing
Graduate
11/10/2014

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Cards

Term
WARFARIN'S STRUCTURE IS SIMILAR TO WHAT?
Definition
VITAMIN K
Term
HOW DOES WARFARIN WORK?
Definition
INHIBITS THE SYNTHESIS OF CLOTTING FACTORS II, VII, IX, AND X. BLOCS THE ACTIVITY OF VITAMIN K, WHICH PREVENTS CARBOXYLATION OF THESE FACTORS.
Term
HOW DOES COUMADIN WORK IN THE PROTEIN C PATHWAY?
Definition
INHIBITS PROTEIN C AND PROTEIN S
Term
DOES COUMAIN DIRECTLY AFFECT PLT ACTIVITY?
Definition
NO! MORE INDIRECT THRU BLOCKING FACTORS AND PROTEINS
Term
IS COUMADIN WELL ABSORBED FROM THE GUT?> WHAT IS THE PKA?
Definition
YES. WEAK ACID WITH PKA OF 5.1
Term
IS COUAMIN HIGHLY PROTEIN BOUND? WHAT CAN IT BE REMOVED FROM ALBUMIN BY?
Definition
YES. FIBRATES
Term
CAN COUMADIN CROSS THE PLACENTA? WHAT WOULD THAT CAUSE?
Definition
YES. CAN CAUSE SEVERE FETAL BLEEDING AND BIRTH DEFECTS
Term
WHAT IS THE ONSET OF COUMAIN? WHAT HAS THE SHORTEST HALF-LIFE?
Definition
12-24 HRS. FACTOR 7 HAS THE SHORTEST HALF LIFE OF ALL THE CLOTTING FACTORS (6 HRS) SO THE ONSET TAKES SEVERAL HALF-LIVES.
Term
THE PEAK COAGULATION EFFECTS OF COUMADIN ARE WHEN?
Definition
36-72HRS
Term
WHAT IS THE 1/2 LIFE, METABOLISM, AND EXCRETION OF COUMAIN?
Definition
24-36 HRS, HEPATIC BY CYP- 450, RENAL
Term
WHAT ARE 2 SIDE EFFECTS WITH COUMAIN?
Definition
BLEEDING AND SKIN NECROSIS (THRU PROTEIN C AND S INHIBITION CAUSING MICRO-CLOTS
Term
COUMAIN EFFECTS ARE INCREASED BY WHAT 7 FACTORS?
Definition
ASA, PLAVIX, NSAIDS, HEPATIC DISEASE, AMIODARONE, HYPERTHYROIDISM (FASTER PRODUCTION OF CLOTTING FACTORS), SOME CEPHALOSPORINS (ELIMINATE INTESTINAL BACTERIA THAT PRODUCE VITAMIN K)
Term
COUMADIN EFFECTS ARE DECREASED BY WHAT 5 FACTORS?
Definition
BARBS (CYP INDUCERS), CHOLESTYRAMINE (COMPETETION OF ABSORPTION), CHLORTHALIDONE (K-SPARING DIURETIC), PHENYTOIN, SPIRINOLACTONE (CAUSES INCREASED BLOOD VISCOSITY), HYPOTHYROIDISM
Term
WRUGS THAT HAVE NO EFFECT ON WARFARIN'S ANTICOAGULANT EFFECTS ARE WHAT 4 DRUGS?
Definition
TYLENOL, OPIOIDS, BENZOS, AND MOST ANTIBIOTICS
Term
HOW DO WE MONITOR THE EFFECTIVNESS OF COUMADIN?
Definition
PT AND INR WHICH IS A MORE ACCURATE JUDGMENT
Term
WHICH PATHWAYS DOES COUMAIN WORK ON?
Definition
EXTRINSIC AND COMMON PATHWAY
Term
WHEN SHOULD COUMADIN BE DISCONTINUED PRIOR TO SURGERY?
Definition
3-5 DAYS PRIOR TO PROCEDURE, CHECK INR PREOPERATIVELY
Term
WHAT SHOULD BE USED FOR REVERSAL FOR COUMAIN?
Definition
FOR URGENT REVERSAL, VITAMIN K 1-10MG IV OR RECOMBINANT FACTOR VIIA OR 1-2 UNITS FFP (HAS ALL CLOTTING FACTORS)
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