Term
| PLAVIX IS A PRODRUG THAT REQUIRES HEPATIC ACTIVATION THROUGH WHAT ENZYME? |
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Definition
| CYP 2D6. IF YOU DON'T HAVE ENOUGH 2D6 THEN IT DOESN'T WORK. |
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Term
| WHAT ARE THE 2 CLINICAL USES OF CY\LOPIDOGREL? |
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Definition
| SAME AS TICLOPIDINE 1) PREVENTION OF THROMBUS IN PATIENTS WHO CANNOT TOLERATE ASA 2) IN COMBINATION WITH ASA FOR PREVENTION OF STENT THROMBUS AFTER CORONARY STENT PLACEMENT. |
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Term
| FOR CLOPIDOGREL AN ORAL LOADING DOSE OF 300MG INHIBITS 80% OF PLT ACTIVITY WITHIN HOW MANT HRS? |
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Definition
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Term
| WHAT ARE 3 SIDE EFFECTS OF CLOPIDOGREL? |
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Definition
| SAME AS TICLIPIDINE, BUT NO LEUKOPENIA. 1) TTP, 2) THROMBOCYTOPENIA, 3) NAUSEA, DYPEPSIA |
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Term
| WHAT LAB SHOULD YOU DRAW WITH CLOPIDOGREL AND WHEN SHOULD YOU DISCONTINUE THE DRUG PRIOR TO SURGERY? |
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Definition
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Term
| WHAT SHOULD YOU GIVE TO HELP REVERSE THE ANTICOAGULANT EFFECTS IF SURGERY IS NEEDED AND THE PT IS ON PLT AND ASA? |
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Definition
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Term
| PRASUGREL (EFFIENT) IS ANOTHER ADP RECEPTOR INHIBITOR. IS IT A PRODRUG LIKE TICLOPIDINE AND CLOPIDOGREL. |
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Definition
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Term
| THE ORAL LOADING DOSE OF 60MG OF PRASUGREL INHIBITS 80% OF PLT AGGREGATION IN APPROX. HOW LONG? |
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Definition
| 2-3 HRS (MUCH FASTER THEN PLAVIX WHICH IS 5 HRS. PRASUGREL IS NOT REVERSABLE. |
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Term
| CAN PRASUGREL BE REMOVED DURING DIALYSIS? |
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Definition
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Term
| HOW MANY TIMES OF PRASUGREL IS THE RISK OF BLEEDING OVER CLOPIDOGREL WHEN DISCONTINUED 4-7 DAYS PREOPERATIVELY? |
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Definition
| 3 TIMES!!!!! GO WITH 7 DAYS B/C BLEEDING IS ALREADY WORSE |
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Term
| IS TRICAGRELOR A PRODRUG JUST LIKE PRASUGREL, CLOPIDOGREL, AND TICLOPIDINE? |
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Definition
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Term
| WHEN SHOULD TRICAGRELOR (BRILLINTA) BE DISCONTINUED PRIOR TO SURGERY? |
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Definition
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Term
| IS TRICAGRELOR (BRILLINTA) REVERSIBLE AND DIALYZABLE? |
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Definition
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Term
| HOW DOES GLYCOPROTEIN IIB/IIIA RECEPTOR ANTAGNISTS WORK? |
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Definition
| BLOCK FIBRINOGEN FROM BINDING TO THE PLT SURFACE, THEREBY LIMITING PLT AGGREGATION. CAN ALSO BLOCK VWF FROM BINDING TO THE PLT. ALSO A GP1B ANTAGONIST TOO. |
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Term
| WHAT ARE 3 DRUGS THAT ARE GLYCOPROTEIN IIB/IIIA RECEPTOR ANTAGNOISTS? |
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Definition
| EPTIFIBATIDE (INTEGRILLIN), TIROFIBAN (AGGRASTAT), ABCIXIMAB (REOPRO) |
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Term
| WHAT ARE 2 CLINICAL USES OF GLYCOPROTEIN IIB/IIIA RECEPTOR ANTAGONISTS? |
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Definition
| 1) ACS 2) PREVENTION OF THROMBUS, MI, AND CORONARY AND CEREBRAL ISCHEMIC EVENTS AFTER CORONARY INTERVENTION |
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Term
| WHAT IS THE MAIN SIDE EFFECT WITH GLYCOPROTEIN IIB/IIIA RECEPTOR ANTAGONISTS? |
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Definition
| BLEEDING AND ANYTHING HAVING TO DO WITH BLEEDING |
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Term
| WHAT ARE 4 CONTRAINDICATIONS WITH GLYCOPROTEIN IIB/IIIA RECEPTOR ANTAGONISTS? |
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Definition
| SAME AS TPA 1) CEREBRAL HEMORRHAGE OR ANY RECENT STROKE W/IN LAST 2 YEARS 2) RECENT SURGERY W/IN LAST 6 WEEKS 3) AV MALFORMATION OR ANEURYSM 4) SEVERE, UNCONTROLLED HTN (MORE LIKELY TO BLOW THE VESSEL). |
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Term
| EPTIFIBATIDE (INTEGRILLIN) AND TIROFIBAN (AGGRASTAT) ARE SIMILAR IN WHICH THEY HAVE PLASMA HALF LIFES OF ONLY ___ BUT THE DURATION OF EFFECT IS UP TO ___. |
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Definition
| 2-4 HRS, 24 HRS STOP INTEGRILLIN AND AGGRASTAT 24 HRS BEFORE SX |
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Term
| ABCIXIMAB (REOPRO) HAS A PLASMA HALF LIFE OF ____ BUT THE PLT EFFECTS LAST ___. |
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Definition
| 12-24HRS, 48-72 HRS. STOP REAPRO 72 HRS BEFORE SURGERY. |
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Term
| WHAT ARE THE 3 TESTS FOR ABCIXIMAB, EPTIFIBATIDE, AND TIROFIBAN? |
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Definition
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Term
| IF YOU TRY TO REVERSE INTEGRILLIN AND AGGRASTAT DOES PLTS HELP? |
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Definition
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Term
| IF YOU TRY TO REVERSE REOPRO WITH PLTS DOES THAT HELP? |
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Definition
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