Term
| An anticoagulant derived from porcine intestinal mucosa. |
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Definition
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Term
| Heparin works by _______ blood clotting reactions without fibrinolytic mechanisms. |
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Definition
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Term
| This anticoagulant can be used to control embolization in A-fib and treat pulmonary embolism. |
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Definition
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Term
| Heparin may cause _________ both locally and systemically. |
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Definition
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Term
| Heparin (regular IV dose) |
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Definition
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Term
| Heparin (AMI loading dose) |
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Definition
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Term
| Heparin (AMI maintenance dose) |
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Definition
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Term
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Definition
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Term
| Abciximab is classified as both an ___________ and ____________. |
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Definition
| Antiplatlet and GPIIb/IIIa inhibitor. |
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Term
| Abciximab works by inhibiting glycoprotein IIb/IIIa receptor in the membrane of the... |
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Definition
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Term
| Abciximab inhibits platlet function for ______hrs. |
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Definition
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Term
| Abciximab (ReoPro) may be indicated in what type of MIs? |
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Definition
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Term
| Abciximab (ReoPro) should not be used if a patient's platlet count is... |
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Definition
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Term
| Abciximab (ReoPro) (post PCI dose) |
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Definition
| 10 mcg/kg/min for 12 hours |
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Term
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Definition
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Term
| Tirofiban HCl (Aggrastat) is classified as an... |
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Definition
| Antiplatlet and GPIIb/IIIa inhibitor. |
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Term
| Tirofiban HCl (Aggrastat) works by inhibiting glycoprotein IIb/IIIa receptor in the membrane of the... |
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Definition
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Term
| Tirofiban HCl (Aggrastat) is made from a protein found in... |
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Definition
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Term
| Following tx w/ReoPro and Aggrastat, platelet functions recovers in... |
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Definition
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Term
| You should D/C anticoagulant use whenever... |
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Definition
| uncontrollable bleeding occurs. |
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Term
| Aggrastat (Tirofiban HCl) should not be used in patients with a platlet count of... |
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Definition
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Term
| The initial dose for Tirofiban HCl is... |
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Definition
| 0.4 mcg/kg/min for 30 minutes |
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Term
| A follow up dose of 0.1 mcg/kg/min of Tirofiban HCl may need to be sustained for... |
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Definition
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Term
| Bivalirudin (Angiomax) is a _______-specific antithrombotic. |
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Definition
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Term
| This drug is a reversible polypeptide thrombin inhibitor which directly inhibits clot-bound and circulating thrombin preventing fibirn generation. |
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Definition
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Term
| Bivalirudin (Angiomax) is derived from... |
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Definition
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Term
| Drug choice for patients with heparin-induced thrombocytopenia and thrombosis syndrome undergoing PCI. |
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Definition
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Term
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Definition
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Term
| When administering Angiomax you should avoid concomitant use with... |
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Definition
| NSAIDs or Aspirin containing products |
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Term
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Definition
| 1 mg/kg IV bolus just before |
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Term
| A subsequent dose of Angiomax may be administered at 0.2 mg/kg/hr for up to... |
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Definition
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Term
| Store prepared Angiomax solutions for 24 hours at....(temp) |
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Definition
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Term
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Definition
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Term
| Exerts its effects by inhibiting fibrin formation through inhibition of activation of factors V, VIII, and XIII; activation of protein C; and platelet aggregation. |
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Definition
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Term
| This drug is highly selective for thrombin with a (Ki) of 0.04 μM. |
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Definition
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Term
| A thrombin inhibitor capable of inhibiting the action of both free and clot-associated thrombin. |
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Definition
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Term
| Exercise caution when administering Argatroban to patients with what impairment? |
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Definition
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Term
| Co-administration of Argatroban and __________ produces a combined effect on INR without additional effect on vitamin K–dependent factor Xa activity. |
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Definition
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Term
| When administering Argatroban the patient's ACT should be checked ___ to ___ minutes after bolus |
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Definition
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Term
| Argatroban (Hepatic Impairment Dose) |
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Definition
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Term
| If your patient still has an ACT of <300s you can administer an additional bolus of Argatroban at what dose? |
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Definition
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Term
|
Definition
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Term
| What three drugs are Glycoprotein (GP) IIb/IIIa inhibitors? |
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Definition
| Integrilin; Abciximab; Tirofiban HCl |
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Term
| Integrilin inhibits platelet aggregation by preventing binding of __________ and other ligans to GP IIb/IIIa receptors. |
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Definition
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Term
| Glycoprotein (GP) IIb/IIIa inhibitors are indicated in ____ MIs. |
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Definition
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Term
| Cautious use of _______ should be exercised in patients with hemorrhagic retinopathy. |
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Definition
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Term
|
Definition
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Term
|
Definition
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Term
| A low molecular weight anticoagulant which indirectly inhibits thrombin generation through other factors. |
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Definition
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Term
|
Definition
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Term
| Lovenox should not be used in patients with a platlet count of... |
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Definition
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Term
|
Definition
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Term
|
Definition
| 1 mg/kg BID with ASA for 2 - 8 days |
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Term
| The reversal agent for heparin is... |
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Definition
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Term
| Protamine sulfate is derived from a protein found in... |
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Definition
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Term
| Used to reverse the effects of heparin post catheterization or coronary artery bypass graft (CABG). |
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Definition
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Term
| Patients with a seafood allergy should not receive what anticoagulant antagonist? |
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Definition
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Term
| Acova inhibits clotting factors... |
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Definition
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Term
| 1 mg of Protamine sulfate neutralizes... |
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Definition
|
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Term
| Protamine sulfate (max dose) |
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Definition
| 50 mg max in a 10 minute period |
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Term
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Definition
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Term
| In adults with AMI, tPA should be used within ___-___hrs from sx onset. |
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Definition
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Term
| While a patient is receiving tPA arterial punctures require ___min of direct pressure. |
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Definition
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Term
|
Definition
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Term
| A patient should receive ____ of tPA in the second and third hours. |
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Definition
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Term
Recombinant plasminogen activator which catalyzes with fibrin
converting plasminogen into plasmin. |
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Definition
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Term
| What two drugs are categorized as thrombolytics? |
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Definition
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Term
|
Definition
| 10 units over 2 min; repeat in 30min |
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Term
| Used to treat coronary thrombus with a new LBBB. |
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Definition
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Term
| Powerful vasoconstrictor used in coronary provocation studies. |
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Definition
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Term
|
Definition
| 1ml, 2ml, 5ml, given 3 - 5 min apart |
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Term
| Ergonivine may cause what necrotic condition? |
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Definition
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Term
| Captopril is a antihypertensive with what other classification? |
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Definition
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Term
| Captopril has what effect on CVP and PCWP? |
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Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
| Time for captopril to reach therapeutic levels is... |
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Definition
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Term
| This drug is considered an analgesic and antiplatlet medication? |
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Definition
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Term
| Impedes hepatic synthesis of blood coagulation factors, possibly via inhibition of vitamin K activity. |
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Definition
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Term
| What form of aspirin should never be used in an emergency? |
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Definition
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Term
|
Definition
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Term
| Aspirin (acute MI dose/route) |
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Definition
| 325mg-650 SL; chewable if available |
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Term
| Aspirin (MI prophylaxis dose) |
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Definition
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Term
| Plavix should be D/C ____days prior to elective surgery. |
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Definition
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Term
|
Definition
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Term
| Inhibits subsequent ADP-mediated activation of the glycoprotein IIb/IIIa complex. |
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Definition
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Term
| Inhibition of conversion of angiotensin I to angiotensin II, blocking vasopressor activity and aldosterone secretion. |
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Definition
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Term
|
Definition
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Term
| If possible, discontinue any diuretics for 2 to 3 days prior to first dose of enalapril to reduce incidence of __________. |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| You may administer up to 5 mg of Vasotec every ____ hours in hypertensive emergencies. |
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Definition
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Term
| What are the thrombin specific antithrombotics? |
|
Definition
| Argatroban (Acova); Bivalirudin (Angiomax); |
|
|
Term
| What is the half life of Heparin? |
|
Definition
|
|
Term
| What are the two thrombolytics? |
|
Definition
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