Term
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Definition
Indirect Inhibitors of Thrombin IIa & Xa
Direct Thrombin IIa Inhibitors
Inhibitors of Clotting Factors Biosynthesis |
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Term
Indirect Inhibitors of Thrombin IIa & Xa |
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Definition
Heparin (Liquaemin®)
Fondaparinux (Arixtra®)
Dalteparin (Fragmin®)
Enoxaparin (Lovenox®)
Tinzaparin (Innohep®)
MOA: Accelerates the effects of Antithrombin III, inhibits thrombin and factor Xa |
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Term
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Definition
Liquaemin®
All side effects and toxicities involve bleeding
DOA: 2 hours, given IV only
MW: 12,000-15,000
Indirect Thrombin (IIa, Xa) Inhibitor (Heparin) |
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Term
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Definition
Arixtra®
Given SQ
MW: 1727
Specific Xa inhibitor
Indirect Thrombin Inhibitor |
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Term
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Definition
Fragmin®
Given SQ
Indirect Thrombin Inhibitor (LMWH) |
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Term
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Definition
Lovenox®
Given SQ
Indirect Thrombin Inhibitor (LMWH) |
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Term
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Definition
Innohep®
Given SQ
Indirect Thrombin Inhibitors (LMWH) |
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Term
Direct Thrombin (IIa) Inhibitors |
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Definition
Bivalirudin (Angiomax®)
Lepirudin (Refludan®)
Argatroban
Dabigatran (Pradaxa®)
MOA: Binds directly to thrombin and inhibits its action |
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Term
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Definition
Angiomax®
Direct Thrombin Inhibitor |
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Term
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Definition
Refludan®
Direct Thrombin Inhibitor |
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Term
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Definition
No Brand Name
Direct Thrombin Inhibitor |
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Term
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Definition
Pradaxa®
Direct Thrombin Inhibitor |
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Term
Inhibitors of Clotting Factors Biosynthesis |
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Definition
Warfarin (Coumadin®, Jantoven®)
Anisindione (Miradon®)
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Term
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Definition
Coumadin®, Jantoven®
MOA: Inhibits the synthesis of clotting factors II, VII, IX, and X from the liver.
Must monitor INR
Inhibitor of Clotting Factor Synthesis |
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Term
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Definition
Miradon®
Similar MOA as Warfarin, Not used often due to hepatotoxicity
Inhibitor of Clotting Factor Synthesis |
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Term
Category 2: Platelet Inhibitors |
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Definition
Inhibitors of Thromboxane A2 Biosynthesis
Inhibitors of ADP Receptors
GP IIb/IIIa Receptor Inhibitors
Additional Antiplatelets |
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Term
Inhibitors of Thromboxane A2 Biosynthesis |
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Definition
Aspirin
MOA: Inhibits prostaglandin synthesis (outside the platelet) and prolongs bleeding
Inhibitor of Thromboxane A2 Biosynthesis |
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Term
Inhibitors of ADP Receptors |
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Definition
Ticlopidine (Ticlid®)
Clopidogrel (Plavix®)
Parsuprel (Effient®)
MOA: Reduces platelet aggregation by inhibiting the ADP receptors, interferes with the activation on fibrin |
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Term
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Definition
Ticlid®
Inhibitor of ADP receptors |
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Term
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Definition
Plavix®
Inhibitor of ADP Receptors |
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Term
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Definition
Effient®
Inhibitor of ADP Receptors |
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Term
GP IIb/IIIa Receptor Inhibitors |
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Definition
Eptifibatide (Integrilin®)
Tirofiban (Aggrastat®)
Abciximab (ReoPro®)
MOA: Blocks the GP IIb/IIIa recpetors which serve as the primary receptor for fibrinogen; blocks the final pathway in platelet aggregation |
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Term
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Definition
Integrilin®
GP IIb/IIIa Receptor Inhibitor |
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Term
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Definition
Aggrastat®
GP IIb/IIIa Receptor Inhibitor |
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Term
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Definition
ReoPro®
GP IIb/IIIa Receptor Inhibitor |
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Term
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Definition
Dipyridamole (Persantine®)
Cilostazol (Pletal®)
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Term
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Definition
Persantine®
Other Antiplatelets |
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Term
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Definition
Pletal®
Other Antiplatelets |
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Term
Category 3: Fibrinolytics |
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Definition
Streptokinase (Streptase®)
Alteplase (Activase®)
Reteplase (Retavase®)
Tenecteplase (TNKase®)
Urokinase (Abbokinase®)
MOA: Rapidly lyse thrombi by catalyzing the formation of the serine protease plasmin from its precursor plasminogen |
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Term
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Definition
Streptase®
Injected in the coronary artery
Fibrinolytic |
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Term
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Definition
Activase®
Given as a 2-4 hour IV infusion
Fibrinolytic |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Abbokinase®
Fibrinolytics |
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Term
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Definition
Phytonadione (Mephyton®)
Protamine sulfate
Aminocaproic Acid (Amicar®)
Tranexamic Acid (Cyklokapron®)
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Term
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Definition
Mephyton®, Aqua-Mephyton®
Vitamin K derivative, Used for warfarin toxicity
Coagulants |
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Term
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Definition
No Brand Name
Used for heparin toxicity
Coagulant |
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Term
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Definition
Amicar®
Used in bleeding disorders
Coagulant (Fibrinolytic Inhibitors) |
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Term
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Definition
Cyklokapron®
Used in bleeding disorders
Coagulant (Fibrinolytic Inhibitors) |
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Term
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Definition
Antihemophilic Factor (Factor VII) (Alphanate®)
Factor IX Complex (AlphaNine SD®)
Coagulation Factor VIIa recombinant
(Novo-Seven®)
Anti-inhibitor Coagulant Complex (Autoples T®)
Antithrombin III (Thrombate III®) |
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Term
Antihemophilic Factor (Factor VII) |
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Definition
Alphanate®, Bioclate®, Helixate®, Hemofil M®, Koate-HP®, Kogenate®, Monoclate®, Recombinate®
Plasma Fractions |
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Term
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Definition
AlphaNine SD®, Bebulin VH®, Benefix®
Plasma Fractions |
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Term
Coagulation Factor VIIa recombinant |
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Definition
Novo-Seven®
Plasma Fractions |
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Term
Anti-inhibitor Coagulant Complex |
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Definition
Autoples T®, Feiba VH Immuno®
Plasma Fractions |
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Term
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Definition
Thrombate III®
Plasma Fractions |
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