Term
| What is the primary action of Anticoagulants? |
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Definition
| Decreases formation of FIBRIN, primarily used to prevent venous thrombosis. |
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Term
| What is the primary action of Antiplatelet drugs? |
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Definition
| Suppresses platelet aggregation, primarily used to treat ARTERIAL thrombosis |
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Term
| What is the primary action of Thrombolytics? |
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Definition
| Promotes breakdown of fibrin, primarily used to dissolve NEW THROMBI |
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Term
| Define Arterial Thrombosis |
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Definition
| Created in arteries usu secondarily to damage to arterial wall, causes platelet adherence, aggregation, then blood slows and fibrin forms. LOCALIZED tissue damage. |
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Term
| Define Venous thrombosis: |
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Definition
| Develops where blood flow is slow, Fibrin forms, clot forms, embolus can form and distal damage can result. |
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Term
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Definition
| FAST ACTING, anticoagulant, promotes AntiThrombin inactivation of clotting factors, used for DVT and Pregnancy, injection only |
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Term
| Advantages of LMW Heparin? Disadvantages? |
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Definition
| Can be given on fixed dose schedule and doesn't require aPTT monitoring; LMW's cost MORE |
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Term
| What lab values do you monitor for Heparin therapy? |
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Definition
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Term
| What is the antidote to Heparin? |
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Definition
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Term
| What is HIT (heparin induced thrombocytopenia)? |
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Definition
| It is an immune reaction against heparin/platelet protein complexes that reduces platelet count and causes endothelial damage and clotting |
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Term
| Compare HEPARIN and COUMADIN |
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Definition
| Heparin fast acting, injection only--Coumadin takes days and is oral |
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Term
| What is the antidote to Warfarin? |
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Definition
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Term
| What lab values do you monitor for Warfarin therapy? |
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Definition
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Term
| What are the uses of Heparin? |
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Definition
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Term
| What are the uses of LMW Heparin? |
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Definition
| Prevention of DVT and ischemic complications, Tx of established DVT |
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Term
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Definition
| Antiplatelet, irrev. ihi of cyclooxygenase (TAX2)--GI BLEED |
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Term
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Definition
| Block ADP receptors/block GP 2a/3b from connecting to fibrin |
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