Term
static or cidal?
Macrolides |
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Definition
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Term
static or cidal?
Tetracyclines |
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Definition
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Term
static or cidal?
Chloramphenicol |
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Definition
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Term
static or cidal?
Clindamycin |
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Definition
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Term
static or cidal?
Gentamicin |
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Definition
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Term
static or cidal?
Streptomycin |
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Definition
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Term
static or cidal?
Neomycin |
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Definition
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Term
static or cidal?
Tobramycin |
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Definition
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Term
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Definition
Macrolide accumulates in Gram (+) bacteria and binds 50s subunit (esp in Macrophages)
-especially effective against Listeria
Tx: H. flu, Legionella, Chlamydia, Gonorrheae, Mycoplasm
*Interact w/ Magnesium/Aluminum |
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Term
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Definition
Macrolide, accumulates in G+ bacteria and binds 50s subunit (inhibits translocation)
Tx: Mycobacterium avium (AIDS)
*Potent inhibitors of P450 (CYP3A4)
*Can increase serum theophylline levels & rifampin/rifabutin can lowe clarithromycin levels |
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Term
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Definition
Macrolide, binds 50s subunit inhibits translocation
-stimulates GI motility
Tx: mycoplasma pneumonia, legionella
*Potent inhibitors of P450 (CYP3A4)
*Can prolong QT interval, can cause cholestatic jaundice |
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Term
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Definition
Tetracycline, binds 30s (blocks binding of aa tRNA)
-pumped into bacteria
Tx: Rickettsia, Cholera, Spirochetes (lyme/syphilis)
*Can bind bone (bad for kids/nursing)
resistance caused by efflux pump
Can get photosensitivity |
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Term
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Definition
Binds to 50s, blocks peptide bond formation
-Good CNS drug (use for abcesses, meningitis, typhoid fever, conjunctivitis)
resistance: plasmid that acetylates drug (no longer binds)
*Aplastic Anemia, Gray baby syndrome
Antagonist of Erithromycin and Clindamycin |
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Term
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Definition
Binds 50s subunits, inhibits translocation (passively enters bacteria)
-Used for anaerobic infections
*Potentiates NM blockers, antagonizes Chloramphenicol/Macrolides |
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Term
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Definition
Aminoglycoside (only effective against Aerobic, porin pump needs ATP + O2)
Tx: Gram- aerobic (Pseudomonas, Enterobacter, Proteus, Klebsiella)
**Ototoxicity and Nephrotoxicity (auditory damage to fetus), NM blockade |
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Term
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Definition
Aminoglycoside (only effective against Aerobic, porin pump needs ATP + O2)
Tx: Gram- aerobic (Pseudomonas, Enterobacter, Proteus, Klebsiella)
**Ototoxicity and Nephrotoxicity (auditory damage to fetus), NM blockade |
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Term
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Definition
Aminoglycoside (only effective against Aerobic, porin pump needs ATP + O2)
Tx: Gram + aerobic (S. viridans, S. agalactiae, Enterocccus)
**Ototoxicity and Nephrotoxicity (auditory damage to fetus), NM blockade |
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Term
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Definition
Aminoglycoside (only effective against Aerobic, porin pump needs ATP + O2)
Tx: Gram + aerobic (S. viridans, S. agalactiae, Enterocccus)
**Ototoxicity and Nephrotoxicity (auditory damage to fetus), NM blockade |
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