Term
|
Definition
| peptidoglycan exposed outside, appears biolet |
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Term
|
Definition
| peptidoglycan covered so takes up alternet stain pink |
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Term
|
Definition
| discovered penicillium fungi |
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Term
|
Definition
work with peptidoglycan bacteria, inhibits cell wall synthesis
penicillins
cephalosporins
carbapenems/monobactams |
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Term
|
Definition
extended spectrum: ampicillan, amoxicillin
anti-staph: methicillin, Oxacillin
administration depends on acid stability |
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Term
|
Definition
one of only penicillin that can oral administer
poorly absorbed in GI tract, kidney elimination sole |
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Term
| Penicillin resistance includes... |
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Definition
B lactamase to metabolize antibiotic
altered penicillin binding ptn
decreased permeability to drugs
clavulanic acid, sulbactam, tazobactam |
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Term
|
Definition
two different R-groups,
functional diversity
more resistant to B lacatmase
lower allergy reaction
improved oral availability |
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Term
|
Definition
carbapenem: so broad B lactam
Monobactam: narrow ass spectrum B lactam
Highy resistant to B lactamase |
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Term
| B lactams are innefective against |
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Definition
| myobacteria, fungi, viruses, humans |
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Term
|
Definition
| any infection with gram + - bacteria |
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Term
|
Definition
Allergic Reaction
Diarrhea - kills GI tract flora
Platelet dysfunction
Interstitial nephritis |
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Term
|
Definition
cant really do much about it
altered penicillin binding proteins
decreased permeability to drug |
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Term
|
Definition
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Term
|
Definition
does what a B lactam does but is not a B lactam, for peopel allergic to them.
must IV
renal elimination |
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Term
|
Definition
local pain
thrombocytopenia
nephrotoxicity |
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Term
|
Definition
Tetracycline, Doxycycline, Minocycline
jews the 30s ribosome
GI irritation, hepatic toxicity, renal toxicity, bone growth depression |
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Term
|
Definition
Streptomycin Neomycin, limited spectrum only aerobics
jews 30s, interfere with proofreading
disrupt integrity of bacterial cell membrane
poor F oral, collects in ears
upset GI
fucks with your ears(deafness)
nephrotoxicity |
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Term
|
Definition
Erythromycin, Azithromycin, Clarithromycin
jews 50 ribosome,
metabolized in liver
safe, but upset GI, cardiac, cholestatic jaundice |
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Term
| Dont use macrolides if... |
|
Definition
except azythromycin, patient has liver dysfunction cuz inhibit cyp450
carbamazepine, cyclosporine, warfarin, corticosteroids, digoxin |
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Term
|
Definition
50s subunit
broad spectrum, inhibits peptidyl transferase reaction
cross BBB, metabolized by liver
rarely used - low therpeutic index and bone marrow supression, gray baby syndrome and cyp450 inhibitor |
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Term
|
Definition
50s
same spectrum as penicillin and erythromycin
metabolized by liver
cause diahrrea |
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Term
| Rifamycin: Inhibits mRNA transcription |
|
Definition
TB
induces cyp2d6
hepatotoxicity, induces cyp45
respiratory
cutaneous
abdominal irritation |
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Term
|
Definition
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Term
|
Definition
anti metabolites
sulfonamides inhibit folate synthesis
broad spectrum,
convulsions and hyperglycemia |
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Term
|
Definition
-oxacin
bone infection, anthrax, UTI, STD
dizziness, photosensitivity, tendon rupture, joint disease |
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Term
|
Definition
very safe, binds ergosterol
oral troche or cream |
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Term
|
Definition
severe systemic infection
Toxic (binds to ergosterol but also cholesterol) |
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Term
|
Definition
antifungal creams
miconazole
ketoconazole
rash, burning |
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Term
|
Definition
GI problem
CNS problem
Hepatic problem
DecreaseImmune System |
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Term
|
Definition
stops virus from mounting cell,
influenza
useful for parkinsons |
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Term
|
Definition
| fake DNA building blocks Guanosine Aciclovir |
|
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Term
|
Definition
herpes virus
well tolerated |
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Term
|
Definition
|
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Term
|
Definition
reverse transcriptase inhibitor
headache, poor apetite
rash |
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Term
|
Definition
teratogenic
confusion, memory loss, depression, psychosis |
|
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Term
| saquinovir, ritonavir, indinavir, darunavir |
|
Definition
inhibits viral protease required for assembly of new virions
diabetes, high cholesterol |
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Term
|
Definition
who knows what the fuck this does
will mutate the shit out of your babies
dry mouth, changes in taste, bone pain |
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