Term
STREPTOMYCIN
GENTOMYCIN
TUBROMYCIN
AMIKACIN |
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Definition
-aminoglycoside
-irreversibly binds to 30S ribosome subunit+mRNA. Stops initiation of transcription, and could also cause a mis-sense mutation
-static
-broad range but no anaerobes
-PA administration only
-cannot get into CSF
-nephrotoxic, ototoxic
-synergistic effect w betalactams |
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Term
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Definition
-reversibly binds w 30S and mRNA
-static
-broad range
-if taken w food or dairy or iron or antacids -it won't work
-works INTRACELLULARLY
-depresses bone
-stains teeth |
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Term
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Definition
-chlormycetin w nitrobenzyl ring
-reversibly binds to 50S ribosome subunit and prevents elongation of polypeptide bc stops transpeptidation
-static
-broad
-surpresses bone marrow
-could even work on soem anaerobes |
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Term
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Definition
-macrolide
-reversibly binds 50S ribosome and prevents translocation portion of polypeptide elongation
-Static but could be cidal at high concentrations
-mostly gram+ but some gram-
-works intracellularly
-prescribed to people w strep or pneumococci infections who are allergic to penicillin
-newer ones cause less GI problems and have a longer half-life |
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Term
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Definition
-reversibly bind to 50S and stop peptide bond formation
-static but could be cidal at high concentrations
-mostly for gram+ but some gram-
-too much --> PMEC (C Difficle) |
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Term
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Definition
-analogue of D-alanine
-prevents step1 of cell wall synthesis (synthesis of low molecular weight precursors)
-can bind to 2 enzymes to stop the making of D-ala-L-ala CW precursor
-cidal
-broad
-causes neuron toxicity
-only used for patients w TB |
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Term
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Definition
-large polypeptides w thiazoline ring
-stops stage2 of CW synthesis - dephospho rylation
-cidal
-gram+ only
-applied topically
-system toxicity |
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Term
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Definition
-beta lactam
-stops stage 3 of CW synthesis: transpeptidation
-cidal
-broad
-least side effects |
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Term
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Definition
-large glycopeptide
-stops stage 3 of CW synthesis: transpeptidation
-cidal
-gram+ only
-overuse led to VREs made |
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