Term
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Definition
| naturally produced products produced by one microorganism to inhibit another |
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Term
| characteristics of good antibiotics |
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Definition
| selectively toxicity, able to penetrate host cells, no effect on host defenses, stable, broad spectrum, little/no side effects, does not destroy normal flora |
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Term
| penicillin, ampicillin, cephalosporin, cycloserine, bacitracin, vancomycin |
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Definition
| antibiotics in inhibition of cell wall synthesis |
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Term
| polymixins, gramacidins, tyrocidins |
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Definition
| antibiotics in damage to cytoplasmic membrane |
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Term
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Definition
| antibiotics in inhibition of nucleic acid synthesis |
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Term
| streptomycin, tetracyclines, chloraphenicol, erythromycin |
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Definition
| antibiotics in inhibition of protein synthesis |
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Term
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Definition
| fungus used to make penicillin |
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Term
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Definition
| fungus used to make cephalosporin |
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Term
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Definition
| fungus used to make cycloserine |
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Term
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Definition
| fungus used to make bacitracin |
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Term
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Definition
| fungus used to make erythromycin |
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Term
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Definition
| fungus used to make vancomycin |
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Term
| bacillus and streptomyces |
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Definition
| funguses used to make polymixins, gramacidins, and tyrocidins |
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Term
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Definition
| fungus used to make streptomycin |
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Term
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Definition
| fungus used to make tetracyclines |
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Term
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Definition
| fungus used to make chloraphenicol |
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Term
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Definition
| effects the linking of transpeptides, select against gram positive spirochytes, 1-5% of people are sensitive to PCN not infected by saliva or bile |
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Term
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Definition
| semi-synthetic PCN, strong bacteriocidal, low toxicity |
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Term
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Definition
| marine fungus that is given to people with PCN allergies, inhibits transpeptidation, attacks growing cells, log phase |
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Term
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Definition
| TB therapy, major side effects, effects peptide synthesis |
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Term
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Definition
| frequently found in triple antibiotics, inhibits transport of wall precursor, toxic to human and animal cells |
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Term
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Definition
| binds to tetrapeptide and inhibits transpeptidation |
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Term
| polymixins, gramacidins, tyrocidins |
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Definition
| effects membrane permeability, bacteriocidal, toxic to tissue |
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Term
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Definition
| block mRNA synthesis by binding to DNA dependent RNA polymerase |
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Term
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Definition
| inhibit DNA gyrase, disrupts DNA replication topoisomerase, cut DNA so that it unwinds |
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Term
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Definition
| work against gram negative, non-toxic in small doses, accumulating effects: causes deafness and kidney damage, given to people with disfiguring acne, combine with 30-S subunit of ribosome, mRNA will be misread |
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Term
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Definition
| widely used (broad spectrum), works against gram positive and gram negative, blocks binding of tRNA to 30-S |
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Term
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Definition
| broad spectrum, combines with 23-S subunit of 50-S (blocks peptide bond of formation) |
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Term
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Definition
| works against gram positive and gram negative used with people restraint to PCN, binds to 50-S disrupts transpeptidation, prevents chain elongation |
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Term
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Definition
chemically similar to paramino benzoic acid (PABA)
bacteria. PABA as precursor for THFA (folic acid) synthesis of purines & pyrimadines
(taken up as PABA, but blocks the rest of the cycle
- prevents synthesis of folic acid) |
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Term
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Definition
| antibiotic in inhibition of specific enzyme systems |
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