Term
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Definition
Natural, kills Gram +/-, -Bactericidal with a narrow spectrum
-inactivated by β lactamase,
more stable than G |
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Term
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Definition
Gram (+), more acid stable, resistant to β lactamase
expand spectrum activity
toxic |
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Term
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Definition
Natural, kills Gram +/-, -Bactericidal with a narrow spectrum
-inactivated by β lactamase |
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Term
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Definition
Gram (+), more acid stable, resistant to β lactamase
-expand spectrum activity
-toxic |
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Term
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Definition
Gram (+), more acid stable, resistant to β lactamase
-expand spectrum activity
-toxic |
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Term
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Definition
Gram(-)
-not P. aeruginosa,
penetrate outer membrane, extended spectrum
-effectiveness against Gram (+) weaken
-acid stable, sensitive to β lactamase |
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Term
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Definition
Anti Pseudomonal penicillin, Gram (+), (-), either not effective/somewhat effective against Gram (+), but highly effective against Gram (-) rods
-sensitive to β lactamase, administered parenterally
-toxic |
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Term
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Definition
Anti Pseudomonal penicillin, Gram (+), (-), either not effective/somewhat effective against Gram (+), but highly effective against Gram (-) rods
-sensitive to β lactamase, administered parenterally
-toxic |
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Term
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Definition
| binds to b-lactamase, an additive |
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Term
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Definition
| binds to b-lactamase, an additive |
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Term
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Definition
| binds to b-lactamase, an additive |
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Term
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Definition
| 4 generations, each gets more and more broad the higher you go, prevents peptidoglycan synth. |
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Term
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Definition
Gram (+), inhibits cell wall synth, complex glycopeptide originally produced by Streptomyces orientalis
-used for patients allergic to β lactam antibiotics, MRSA
- Nephrotoxicity, Neurotoxicity, Ototoxic |
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Term
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Definition
Gram (+), cell wall synth, -polypeptide produced by Bacillus subtilis
-topical use
- Nephrotoxicity-if administered parenterally |
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Term
|
Definition
Gram (-) rods, detergent action, isolated from Bacillus polymyxa
-Pseudomonas aeruginosa
-used for Gram (-) rods not responding to other therapy
-used on external, localized infections
-bactericidal
-Nephrotoxicity |
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Term
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Definition
Gram (-) rods, detergent action, isolated from Bacillus polymyxa
-Pseudomonas aeruginosa
-used for Gram (-) rods not responding to other therapy
-used on external, localized infections
-bactericidal
-Nephrotoxicity |
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Term
|
Definition
Gram (+)
Gram (-)
Rickettsial,
-bone seeking drugs
stops synthesis of tRNA (30s subunit binding)
obtained from Steptomyces
-Bacteriostatic – broad spectrum
-intracellular bacteria and UTI pathogens, enterics |
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Term
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Definition
Gram (+)
Gram (-)
Rickettsial,
-bone seeking drugs
stops synthesis of tRNA (30s subunit binding)
obtained from Steptomyces
-Bacteriostatic – broad spectrum
-intracellular bacteria and UTI pathogens, enterics |
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Term
|
Definition
Gram (+)
Gram (-)
Rickettsial,
-bone seeking drugs
stops synthesis of tRNA (30s subunit binding)
obtained from Steptomyces
-Bacteriostatic – broad spectrum
-intracellular bacteria and UTI pathogens, enterics |
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Term
|
Definition
Gram (+)
Gram (-)
Rickettsial,
-bone seeking drugs
stops synthesis of tRNA (30s subunit binding)
obtained from Steptomyces
-Bacteriostatic – broad spectrum
-intracellular bacteria and UTI pathogens, enterics |
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Term
|
Definition
Gram (+)
Gram (-)
Aerobic and anaerobic
Stops 50s subunit binding
Bacteriostatic, broad spectrum
-restricted for treating typhoid fever, plague, rocky moutain spotted fever, penicillin resistant H. influenzae, meningococcal infections
- Hematotoxicity, Reversible aplastic anemia |
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Term
|
Definition
Gram (+)
Gram (-)
block initiation complex,
Broad spectrum, bacteriostatic |
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Term
|
Definition
Gram (+)
Gram (-)
block initiation complex,
Broad spectrum, bacteriostatic |
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Term
|
Definition
Gram (+)
Gram (-)
block initiation complex,
Broad spectrum, bacteriostatic |
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Term
|
Definition
Gram (+)
Gram (-)
block initiation complex,
Broad spectrum, bacteriostatic |
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Term
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Definition
Rifamycins fam
Mycobacterium tuberculosis
-Gram (+) cocci aerobic,
inhibits RNA synth
given in combo with another antibiotic
-bactericidal
-Headache, Dizziness |
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Term
|
Definition
Rifamycins fam
Mycobacterium tuberculosis
-Gram (+) cocci aerobic,
inhibits RNA synth
given in combo with another antibiotic
-bactericidal
-Headache, Dizziness |
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Term
|
Definition
Rifamycins fam
Mycobacterium tuberculosis
-Gram (+) cocci aerobic,
inhibits RNA synth
given in combo with another antibiotic
-bactericidal
-Headache, Dizziness |
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Term
|
Definition
Quinolones
(Fluoroquinolone fam
Enterococci
Gram (-)
Aerobes,
inhibits uncoiling of DNA,
synthetic fluorinated analogs of nalidixic acid-broad spectrum antibiotics, bactericidal
-used for UTI
-Low toxicity |
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Term
|
Definition
Quinolones
(Fluoroquinolone fam
Enterococci
Gram (-)
Aerobes,
inhibits uncoiling of DNA,
synthetic fluorinated analogs of nalidixic acid-broad spectrum antibiotics, bactericidal
-used for UTI
-Low toxicity |
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Term
|
Definition
Quinolones
(Fluoroquinolone fam
Enterococci
Gram (-)
Aerobes,
inhibits uncoiling of DNA,
synthetic fluorinated analogs of nalidixic acid-broad spectrum antibiotics, bactericidal
-used for UTI
-Low toxicity |
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Term
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Definition
anaerobic bac, and protozoans,
narrow spectrum
treatment of intra-abdominal infections, vaginitis, antibiotic associated entercolitis, brain abscesses
-bactericidal
-Fever, Nausea |
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Term
|
Definition
sulfonamide
Gram (+)
Gram (-),
competes with foliate synth
-broad spectrum, bacteriostatic
-used for uncomplicated UTIs, otitis media, abscesses
-Nausea, Rash |
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Term
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Definition
sulfonamide
Gram (+)
Gram (-),
competes with foliate synth
-broad spectrum, bacteriostatic
-used for uncomplicated UTIs, otitis media, abscesses
-Nausea, Rash |
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Term
|
Definition
sulfonamide
Gram (+)
Gram (-),
competes with foliate synth
-broad spectrum, bacteriostatic
-used for uncomplicated UTIs, otitis media, abscesses
-Nausea, Rash |
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Term
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Definition
inhibits foliate synth, bacteriostatic, bactericidal
-used in combo with sulfamethoxazole to treat UTI, otitis media, respiratory tract infection, diarrhea (combo synergistic)
-Visual disturbances |
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Term
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Definition
Leprosy bacillus, inhibits folic acid synthesis, sulfa drug, treat leprosy, usually in combo with other antimycobacterial drugs (rifampin and clofazimine)
-treat Pneumocystis carinii pneumonia
-bacteriostatic
-GI discomfort |
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Term
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Definition
Tuberculosis, bacillus
inhibits mycolic acid synth,
bactericidal against growing organisms, bacteriostatic against non replicating organisms
-Neurotoxicity, Hepatotoxicity |
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Term
|
Definition
Candidiasis
GI fungal infections,
interact with sterols, topical, too toxic for systemic |
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Term
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Definition
Systemic candidiasis, and exotic mycoses,
interacts with sterols,
Can be used IV
Considerable toxicity issues |
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Term
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Definition
Fungi and some G(+) cocci, Blocks synthesis of ergosterol,
Oral gel or cream
Rarely find resistant strains of yeast |
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Term
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Definition
Blocks synthesis of ergosterol
Minor toxicity, Used as a prophylactic chemotherapy for HIV infected patients |
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Term
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Definition
| Broader spectrum antifungal, includes Aspergillus, Blocks synthesis of ergostero, Does not penetrate CNS (not used for meningitis patients), has increased toxicity issues |
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Term
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Definition
Used in systemic candidiasis and aspergillosis, block cell wall in fungi,
Penicillin of antifungals |
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Term
|
Definition
Dermatophyte infections, Blocks synthesis of ergosterol
Topical or tablet. Increased toxicity when used in tablet form |
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