Shared Flashcard Set

Details

Antibiotics
Antibiotics for A&D 2011
36
Medical
Graduate
01/20/2011

Additional Medical Flashcards

 


 

Cards

Term
Carbapenem drug
Definition
Meropenem, a beta lactam antibiotic
Term
meropenem niche
Definition
nosocomial infections, febrile neutropenia, ...
Term
Vancomycin mechanism of action
Definition
Bactericidal. Works by inhibiting cell wall synthesis (not in the same way as beta lactams), in the transpeptidase reaction, it binds to the terminal D-Ala-D-Ala of the newly formed (nascent) peptidoglycan and prevents linkage.
Term
Vancomycin niche
Definition
Treatment of MRSA and other resistant gram positives.
Term
Vancomycin toxicities
Definition
Not absorbed from GI tract, adjunct to beta-lactams in CNS infections if resistant gram positives.
Red-man syndrome - histamine-related infusion reaction, give antihistamines and infuse slowly.
Oto and renally toxic. Renally cleared, watch levels closely in people with renal issues.
Term
Vancomycin spectrum
Definition
Gram positives, especially resistant ones.
Term
MRSA
Definition
Methicillin resistant staph aureus
Term
Bacterial ribosomes
Definition
30s+50s = 70s
Term
Aminoglycoside example
Definition
gentamicin
Term
drugs affecting 30s subunit
Definition
gentamicin (aminoglycoside), doxycycline (tetracycline)
Term
drugs affecting 50s subunit
Definition
azithromycin (macrolide), clindamycin, linezolid
Term
gentamicin niche
Definition
aerobic gram negative rods, synergistic with cell wall active agents (beta-lactams and vancomycin) for gram positive cocci.
Term
gentamicin toxicity
Definition
nephrotoxicity and 8th cranial nerve (hearing and balance), must monitor serum levels. Toxicities of concern when combine with vancomycin.
Term
gentamicin spectrum
Definition
Aerobic gram negative rods.
Term
gentamicin mechanism of action
Definition
Bacteriocidal. Must get to 30s ribosome by entering the cell, cell-wall breakdown by cell wall active agents helps it get through.
Term
tetracycline example
Definition
doxycycline
Term
doxycycline niche
Definition
Think weird bugs (rickettsiae, leptospirosis [a spirochete], rocky mountain spotted fever). Cutaneous outpatient MRSA skin infection (people who get put on vancomycin in the hospital get sent home with this drug).
Term
doxycycline mechanism of action
Definition
Bacteriostatic. Inhibits the 30s ribosomal subunit.
Term
doxycycline toxicity
Definition
diarrhea, vaginal yeast infections, photsensitivity. Stains teeth of fetuses and children brown -- avoided in children!!
Term
doxycycline spectrum
Definition
Many gram positives (including MRSA), gram negatives, mycoplasma, chlamydiae, rickettsiae.
Term
doxycycline structure
Definition
Comprised of four cyclic rings with four modification sites, ripe for modification to make new drugs.
Term
azithromycin niche
Definition
Bacterostatic. Upper respiratory infections (think: Z-pak), pneumonia, genital chlamydia infections (give one dose and you're done!)
Term
azithromycin mechanism of action
Definition
inhibits 50s ribosomal subunit
Term
azithromycin toxicities
Definition
Well-tolerated, GI-upset common, drug-drug interactions
Term
azithromycin spectrum
Definition
strptococci, staph auresu, h.flu, atipical bacteria including mycoplasma, chlamydiae, legionella.
Term
clindamycin
Definition
Term
linezolid
Definition
Term
Trimethoprim/Sulfmethoxazole mechanism of action
Definition
Term
Trimethoprim/Sulfmethoxazole niche
Definition
Term
Trimethoprim/Sulfmethoxazole toxicities
Definition
Term
Trimethoprim/Sulfmethoxazole spectrum
Definition
Term
fluoroquinolone example
Definition
ciprofloxacin
Term
ciprofloxacin mechanism of action
Definition
Term
ciprofloxacin niche
Definition
Term
ciprofloxacin toxicities
Definition
Term
ciprofloxacin spectrum
Definition
Supporting users have an ad free experience!