Term
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Definition
| Meropenem, a beta lactam antibiotic |
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Term
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Definition
| nosocomial infections, febrile neutropenia, ... |
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Term
| Vancomycin mechanism of action |
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Definition
| Bactericidal. Works by inhibiting cell wall synthesis (not in the same way as beta lactams), in the transpeptidase reaction, it binds to the terminal D-Ala-D-Ala of the newly formed (nascent) peptidoglycan and prevents linkage. |
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Term
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Definition
| Treatment of MRSA and other resistant gram positives. |
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Term
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Definition
Not absorbed from GI tract, adjunct to beta-lactams in CNS infections if resistant gram positives.
Red-man syndrome - histamine-related infusion reaction, give antihistamines and infuse slowly.
Oto and renally toxic. Renally cleared, watch levels closely in people with renal issues. |
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Term
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Definition
| Gram positives, especially resistant ones. |
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Term
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Definition
| Methicillin resistant staph aureus |
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Term
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Definition
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Term
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Definition
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Term
| drugs affecting 30s subunit |
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Definition
| gentamicin (aminoglycoside), doxycycline (tetracycline) |
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Term
| drugs affecting 50s subunit |
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Definition
| azithromycin (macrolide), clindamycin, linezolid |
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Term
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Definition
| aerobic gram negative rods, synergistic with cell wall active agents (beta-lactams and vancomycin) for gram positive cocci. |
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Term
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Definition
| nephrotoxicity and 8th cranial nerve (hearing and balance), must monitor serum levels. Toxicities of concern when combine with vancomycin. |
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Term
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Definition
| Aerobic gram negative rods. |
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Term
| gentamicin mechanism of action |
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Definition
| Bacteriocidal. Must get to 30s ribosome by entering the cell, cell-wall breakdown by cell wall active agents helps it get through. |
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Term
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Definition
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Term
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Definition
| Think weird bugs (rickettsiae, leptospirosis [a spirochete], rocky mountain spotted fever). Cutaneous outpatient MRSA skin infection (people who get put on vancomycin in the hospital get sent home with this drug). |
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Term
| doxycycline mechanism of action |
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Definition
| Bacteriostatic. Inhibits the 30s ribosomal subunit. |
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Term
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Definition
| diarrhea, vaginal yeast infections, photsensitivity. Stains teeth of fetuses and children brown -- avoided in children!! |
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Term
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Definition
| Many gram positives (including MRSA), gram negatives, mycoplasma, chlamydiae, rickettsiae. |
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Term
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Definition
| Comprised of four cyclic rings with four modification sites, ripe for modification to make new drugs. |
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Term
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Definition
| Bacterostatic. Upper respiratory infections (think: Z-pak), pneumonia, genital chlamydia infections (give one dose and you're done!) |
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Term
| azithromycin mechanism of action |
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Definition
| inhibits 50s ribosomal subunit |
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Term
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Definition
| Well-tolerated, GI-upset common, drug-drug interactions |
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Term
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Definition
| strptococci, staph auresu, h.flu, atipical bacteria including mycoplasma, chlamydiae, legionella. |
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Term
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Definition
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Term
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Definition
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Term
| Trimethoprim/Sulfmethoxazole mechanism of action |
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Definition
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Term
| Trimethoprim/Sulfmethoxazole niche |
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Definition
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Term
| Trimethoprim/Sulfmethoxazole toxicities |
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Definition
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Term
| Trimethoprim/Sulfmethoxazole spectrum |
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Definition
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Term
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Definition
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Term
| ciprofloxacin mechanism of action |
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Definition
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Term
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Definition
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Definition
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Definition
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