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Antibiotics IV
Cell Wall stuff
10
Medical
Professional
04/24/2013

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Cards

Term
Penicillin
Definition
Blocks TRANSPEPTIDASE CROSSLINK.. CIDAL

gm+/gm-(weak)/anerobic/spirochete

POOR CNS
1. extensive skin rashes esp. with mono

REALLY GM + and TREP PAL
Term
Amoxicillin
Definition
Extended spectrum penecillin which blocks transpeptidase crosslink

gm+/gm-/anerobic/spirochete

POOR CNS
skin rashes with mono

SINUSITIS
Term
Nafcillin
Definition
For Staph... blocks transpeptidase crosslink

MRSA = MUTATED PENECILLIN BINDING PROTEIN.

gm+narrow/gm-/anerobic/spirochete... decreased sensitivity to lactamase

POOR CNS
skin rashes with mono
Term
Piperacillin
Definition
for pseudomonas blocks transpeptidase crosslinking

gm+/gm-/anerobic/spirochete

POOR CNS
skin rashes with mono

COMBINED AMINOGLYCOSIDE
Term
Cefazolin
Definition
1st generation cehpalosporine binds penecillin bind protein

gm+/- and Spirochetes

REALLY SURGICAL PROPHYLAXIS GM +
NEPHROTOXIC

ok delayed hypersensity penecillin

Proteus, E.coli, Klebsiella
Term
Ceftriaxone
Definition
3rd generation cephalosporine bind pbp

gm+/- and spirochetes
GOOD CNS
PNEUMONIA AND GM -

ok delayed hypersensity penecillin

MENINGITIS AND GONORRHEA
Term
cefepime
Definition
4th generation cephalosporine bind pbp

gm +/- and spirochetes
GOOD CNS
GAINED PSEUDOMONAS

NEPHROTOXIC

ok delayed hypersensity penecillin
Term
ceftaroline
Definition
5th generation cephalosporine bind pbp

gm +/- and spirochetes
MRSA-co and MRSA-skin

NEPHROTOXIC

ok delayed hypersensity penecillin
Term
B-lactamases
Definition
secreted grm positive
in periplasm grm negitive

break lactam ring
Term
cephlasporins in general SE
Definition
1. hypersensitivity rxns
2. increases nephrotoxicity of aminoglycosidese
3. disulfram like reactions
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