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Antibiotics II- IDIT
n/a
37
Pharmacology
Professional
02/08/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
sulfisoxazole
Definition

available alone or w/ erythromycin for use in recurrent otitis media

 

oral sulfonamide

Term
sulfamethoxazole
Definition

available w/ trimethroprim aka co-trimoxazole, TMP-SMZ

 

as synergistic effect

 

used for RUG (resp, urinary, GI)

Term
sulfacetamide
Definition

opthalmic sulfonamide

 

used for ulcerative blepharitis, bacterial conjuntivitis

Term
Silver sulfadiazine
Definition

prevents sepsis from burns, silver released is toxic

 

caution: the sulfa can be absorbed if covering large area

 

a topical sulfonamide

Term
mafenide
Definition

for burns, limited use because inhibit carbonic anhydrase. this can lead to metabolic acidosis

 

topical sulfonamide

Term
ciprofloxacin
Definition

best FQ for G-

 

decreases clearance of thephylline, methadone, tizanidine

 

binds to CYP450

2nd generation FQ

Term
Norfloxacin
Definition

UTI only

 

2nd generation FQ

Term
ofloxacin
Definition

oral is generic

 

2nd generation FQ

Term
gatifloxacin
Definition

3rd generation FQ

 

opthalmic solution only

Term
gemifloxacin
Definition
3rd generation FQ
Term
levofloxacin
Definition

avoid if there are conduction anomalies

 

increased risk of prolonging Q-T interval in elderly: torsades de pointes

 

3rd generation FQ

Term
Moxifloxacin
Definition

metabolized mainly in liver (caution if hepatic disease is present)

 

can prolong Q-T interval in healthy pts

 

3rd generation FQ

Term
Besifloxacin
Definition

approved for bacterial conjuntivitis

 

4th generation FQ

Term
PCN G
Definition

aka benzylPCN

 

IM/IV

 

can enter CNS if meninges are inflammed

Term
aqueous PCN G
Definition
solution IV/IM
Term
procaine
Definition

suspension IM only

 

procaine is a local anesthetic

 

 

Term
Bicillin CR
Definition

controlled release

 

PCN G + procraine + benzathine

Term
Bicillin L-A
Definition

long acting

 

benzathine + PCN G

Term
PCN V
Definition

aka phenoxymethylPCN

 

oral form

 

food interferes with absorption

Term
dicloxacillin
Definition

PCNase resistant PCN

 

oral

Term
Oxacillin
Definition

PCNase resistant PCN

 

parenteral

Term
Nafcillin
Definition

PCNase resistant PCN

 

parenteral

Term
ampicillin
Definition

oral or IV

 

aminoPCNs- extended spectrum

 

w/ sulbactam (beta-lactamase inhibitor)

 

used for peritonitis cause by B. fragilis

Term
amoxycillin
Definition

tablets, oral suspension, pediatric drop

 

better oral absorption than ampicillin

 

longer t1/2 than ampicillin

 

available with clavulanate aka co-amoxiclav

 

used to finish treatment of peritonitis (can't use to start because too slow)

 

Term
Ticarcillin + clavulanate
Definition

antipseudomonas PCN

 

parenteral

Term
piperacillin + tazaobactam 
Definition

antipseudomonas PCN

 

parenteral 

Term
cefazolin
Definition

IV

 

1st generation cephalosporin

Term
cephalexin
Definition

oral

1st generation cephalosporin

 

Term
cefadroxil
Definition

oral 

1st generation of cephalosporin

Term
Cefaclor
Definition

oral every 8h

associated with Sx of serum sickness

 

2nd generation cephalosporin

Term
cefuroxime
Definition

every 12 h

 

2nd generation cephalosporin

Term
cefoxitin
Definition

a cephamycin

 

IV/IM

 

active against B. fragilis

 

Term
cefotetan
Definition

IV/IM

 

methylthiotetrazole side-chain antagonizes vit K, which leads to hypoprothrombinemia

 

must supplement with vit K

2nd generation cephalosporin

Term
ceftriaxone
Definition

IV/IM

 

can cause kernicterus

 

can use with young infants only as one dose for gonorrhea conjuntivitis

 

3rd generation cephalosporin

 

good against meningitis

Term
cefotaxime
Definition

IV/IM

 

will also treat bacteroides

 

parent and metabolite active

Term
cefpodoxime
Definition
oral cephalosporin
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