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Antibiotics II
Nucleic Acid Synthesis
5
Medical
Professional
04/24/2013

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Cards

Term
Ciprofloxacin
Definition
Flouroquinolones: BROAD SPECTRUM BACTERIALCIDAL GYRASE (gram - topoisomerase inhibitor)

mostly gram - and intracellular

resistance = change topoisomerase

Respiratory, UTI, prostatits (poor cns)
conjunctivitis


1. prolongs QT interval
2. neuromuscular junction block
3. epilepsy threshold lowered
4. TENDINOPATHY!!!!!
Term
Moxifloxacin
Definition
Respiratory Flouroquinolones: broad Bacterialcidal topoisomerase inhibitor

mostly gram negitive and intracellular
Gram + = strep pneumo

resistance = change topoisomerase
Respiratory, UTI, prostatits (poor cns)

1. prolongs QT interval
2. neuromuscular junction block
3. epilepsy threshold lowered
5. TENDINOPATHY!!!
Term
Metronidazole
Definition
ANEROBIC BACTERIALCIDE: can enter CNS

resistance = altered nitroreductase

peptic ulcer, wound, clost diff.
1. lowers alcohol dehydrogenase
2. darkens urine
3. periphral neuropathy
Term
Sulfamethoxazole
Definition
Sulfonamide: competitive dihydropteroate syntase inhibitor (THF/nucleoside synthesis)

BROAD BACTERIOSTATIC, CNS

GM +/- and intracellular

r = increased paba or mutated dhpt
CONTRAINDICATED PREGNANCY
1. steven johnson syndrome
2. hemolytic anemia

use uti/pneumocystis, community MRSA
Term
Trimethoprime
Definition
Dihydrofolate reductase inhibitor

r= mutated THFR, good urine/CNS

Gm +/- and intracellular

CONTRAINDICATED FOLATE ANEMIA

UTI/PNEUMOCYST/community MRSA
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