Term
|
Definition
hematologic - neutropenia with high doses
renal - interstitial nephritis
CNS - seizures with high doses
GI
Procaine (IM) - neurologic symptoms if enters bloodstream |
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Term
|
Definition
hematologic - neutropenia with high doses
renal - interstitial nephritis
CNS - seizures with high doses
GI
Amp has higher incidence of rash (esp with allopurinol) and GI. |
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|
Term
|
Definition
-increase LFTs, hepatitis
-neutropenia
-decreases warfarin INR |
|
|
Term
|
Definition
-Neutropenia
-thrombophlebitis
-decreases warfarin INR |
|
|
Term
|
Definition
-Neutropenia
-decreases warfarin INR |
|
|
Term
|
Definition
-hypernatremia
-hypokalemia
-neutropenia, thrombocytopenia
-AIN |
|
|
Term
|
Definition
| GI and hepatotoxicity is worse than with just amoxicillin |
|
|
Term
|
Definition
| cilastin lowers seizure threshold |
|
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Term
|
Definition
-CNS: seizures > elderly, high dose, renal failure. less w mero/dori
-Allergic
-GI
-increase LFTs
-lowers valproic acid conc. by 50% |
|
|
Term
|
Definition
-hypersensitivity
-vaginal yeast overgrowth
-neutropenia, eosinophilia, thrombocytopenia
-increase LFTs |
|
|
Term
|
Definition
|
|
Term
|
Definition
-pseudobiliary lithiasis (stones due to biliary sludging)
-C/I with calcium in neonates (<28 days) use cefotaxime
->28 days, flush lines before calcium products |
|
|
Term
|
Definition
| -disulfuram like rxn (MTT side chain) |
|
|
Term
|
Definition
| can cause red stool, mainly in pts receiving iron products |
|
|
Term
| which cephs interact with antacids, H2 blockers, PPIs |
|
Definition
the produgs: separate by 2 hours
-cefpodoxime
-cefuroxime
-cefditoren |
|
|
Term
| AG tobra, genta, amikacin, stepto |
|
Definition
-ATN (reversible)
-ototoxicity (usually irreversible) auditory and vestibular
-neurotox: neuromuscular blockade (neuropathy, numb, tingling, twitching, convulsions, myasthenia gravis-like) |
|
|
Term
|
Definition
-GI
-QTc
-liver failure
-renal
-tendinitis
-peripheral neuropathy, myasthesia gravis
-CNS |
|
|
Term
|
Definition
-GI
-hypersensitivity
-thrombocytopenia, leukopenia, megaloblastic anemia
-crystalluria (give w lots of water)
-preg D
-C/I infants <2 months
-increases warfarin INR |
|
|
Term
|
Definition
-GI (erythromycin)
-cholestatic jaundice
-thrombophlebitis (IV)
-hearing loss (transient)
-QTc
-myasthenia gravis |
|
|
Term
| telithromycin (macrolide) |
|
Definition
-C/I in myasthenia gravis, hepatitis, colchicine in renal or hepatic impairment
-QTc prolongation
-visual disturbances
-Transient loss of consciousness |
|
|
Term
|
Definition
-GI: diarrhea (c.dif), ab pain
-allergic
-hepatotoxicity (> with IV)
-neutropenia, thrombocytopenia, agranulocytosis
-metallic taste |
|
|
Term
|
Definition
-CNS: *peripheral neuropathy*
-GI and metallic taste
-pancreatitis (rare)
-disulfiram rxn
-urine discoloration
-C/I 1st trimester
-interacts with warfarin |
|
|
Term
|
Definition
-teeth and bones
-photosensitivity
-esophageal ulcerations and other GI adrs
-intracranial HTN +/- visual field loss
-hepatotoxicity and increase BUN w diuretic |
|
|
Term
|
Definition
| -CNS: vertigo, tinnitus (2nd and 3rd day) -bluish gray nail, skin and sclera pigment -autoimmune disorders: lupus, hepatitis, serum sickness, vasculitis, pneumonoitis |
|
|
Term
|
Definition
-teeth discoloration, photosensitivity
-NAUSEA, VOMITING, DIARRHEA
-rash
-pancreatitis
-INCREASED ALL-CAUSE MORTALITY!! |
|
|
Term
|
Definition
-ATN
-dizziness, visual disturbances
-neuromuscular blockade, resp failure or apnea
-areosolized therapy: bronchoconstriction |
|
|
Term
|
Definition
-nephrotoxicity
-ototoxicity
-red man syndrome
-thrombocytopenia, neutropenia, thrombophlebitis |
|
|
Term
|
Definition
-venous irritation (give centrally)
-elevated conjugated bilirubin
-arthlagias and myalgias (30%, very painful)
-n/v/d, rash |
|
|
Term
|
Definition
-myelosuppression, thrombocytopenia
-n/d/HA
-lactic acidosis
-peripheral and optic neuropathy
-convulsions |
|
|
Term
|
Definition
-muscle pain or weakness in distal extremeties
-eosinophilic pneumonia
-peripheral neuropathy |
|
|
Term
|
Definition
-n/v
-pulmonary, irreversible pul fibrosis
-hepatitis
-hemolytic anemia w g6pd deficiency
-peripheral neuropathy
-beers list |
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