Term
| What are the indications for slowing the rate of rise of the action potential and increase action potential duration and the effective refractory period? |
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Definition
Class 1A
Quinidine
Procainamide |
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Term
| What drugs bind to Na channel and prevents Na influx with changes in AP and indicate for supraventricular and ventricular arrhythmias by transforming unidirectional block into a bi-directional block? |
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Definition
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Term
| What are the toxicity of quinidine? |
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Definition
| may cause SA and AV block, induce tachycardia, and increase Digoxin levels |
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Term
| What drugs convert to NAPA, eliminated by kidney, given oral and IV? |
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Definition
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Term
| What are the toxicity of Procainamide? |
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Definition
| reversible lupus syndrome and less atropine like effects than quinidine |
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Term
| Which antiarryhthmics drugs have little effect on the rate of AP depolarizaiton, but rather decreases the AP duration and the effective referactory period? |
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Definition
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Term
| What drug have rapid associate and disassociate from Na channel, shortens phase 3 repolarization and decreases the duration of Ap and the ERP w/o much decresae in phase 0? |
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Definition
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Term
| Which drug suppress the Ventricular arrhythmias caused by abnormal automaticity b/c it can decrease slope of phase 4? |
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Definition
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Term
| What drug is eliminated by the liver (P450, local anesthetics), mainly used in emergency treatment of Ventricular arrhythmias during MI? |
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Definition
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Term
| What Antiarrhythmic is used to markedly depress rate of rise of the AP thus causing marked slowing of conduction velocity but have little effect on AP duration or ERP? |
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Definition
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Term
| Which drug is only approved for Refractory Arrhythmias and dissociate more slowly from Na channels and show prominent effects even at normal HR? |
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Definition
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Term
| Which drug is used for severe pain, subQ, IM/IV, oral, morphine+++, dynorphin+, enkephalin+? |
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Definition
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Term
| Which drug is used as orally effective, 1-1/2 the potency of morphine, analgesic for mild moderate pain and ANTITUSSIVE? |
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Definition
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Term
| Which drug is used more potent than morphine and 4-6 hrs of action, abuse potential and used in other countries? |
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Definition
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Term
| Which drug is similar to morphine but 10 times more potent? |
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Definition
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Term
| Which synthetic drug is 1/10 potency of morphine, used for moderate to severe pain, commonly used in obstetrics (less respiratory depression than morphine i newborn)...short acting...active metabolite normeperidine may cause seizures, morphine+++, dynorphin+, enkephalin+? |
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Definition
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Term
| Which drug is less euphoric and Long duration (12-14)hrs and used as analgesic in TREATING OPIOID ADDITION? |
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Definition
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Term
| Which drug is used for mild to moderate pain, usually with ACETAMINOPHEN? |
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Definition
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Term
| Which drug is no damn good, NDG, much less potent than all the rest, but high toxicity? |
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Definition
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Term
| Which drug is very potent morphine agonist, 100 times more potent than morphine, administration with NO in conjuntion with Innovar will produce a state called Neuroleptic Anesthesia, Russian hostage situation? |
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Definition
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Term
| Which drug choice for opioid poisoning and can reverse resp effects, must be given paraenrerally, can precipitate withdrawals in addicts:"Naloxone challenge", m-,k-,e-? |
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Definition
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Term
| Which drug orally effective, long acting, used in "immunizing addicts" (preventing the high produced by opioid agonists), HEPATOTOXICITY, somewhat used for treatment of alcoholism? |
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Definition
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Term
| Which drug is agonist effects are dominant (k+,partial morphine), morphine-antagonist at high doses, less effective than morphine for severe pain, but sedation and resp. depression is less, however CNS stimulation are worse? |
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Definition
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Term
| Which drug is partial agonist (3/4agonist) at morphine and possibly dynorphin, abuse potential MUCH LOWER, treatment for heroine addiction, SUBOXONE (buprenorphine and naloxone), office-based treatment of Opioid Dependance, doesn;t have as tight of controls as methadone? |
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Definition
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Term
| Which drug is used as like Pentazoncine and parenteral? |
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Definition
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Term
| Which drug is used as new drug for mild to moderate pain, weak morphine agonist, additional NE and 5-HT reuptake inhibitor (much like tricyclics), good analgesia with mild side effect true effects remain to be seen? |
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Definition
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