Term
|
Definition
| - reduction below normal in the number of erythrocytes or the quantity of hemoglobin |
|
|
Term
|
Definition
- destruction of the bone marrow
- often by cytotoxic drugs |
|
|
Term
|
Definition
- resulting from aplasia
- loss of hematopoetic tissue in the bone marrow |
|
|
Term
|
Definition
| - deficiency in RBC production |
|
|
Term
|
Definition
|
|
Term
|
Definition
- Iron deficiency
- anemia of chronic disease
- sideroblastic |
|
|
Term
|
Definition
- anemia of chronic diseases
- endocrine anemia
- bone marrow failure |
|
|
Term
|
Definition
| - deficiencies of B12 and folic acid |
|
|
Term
|
Definition
- genetically predetermined hemolytic anemia
- common in Mediterranean populations
- Cooley's: Beta thalassemia major |
|
|
Term
|
Definition
- Recombinant human GM CSF
- promotes the proliferation & differentiation of progenitor cells for granulocytes & macrophages
- Acts w/ stem cell factors & interleukins increases neutrophils and monocyte production |
|
|
Term
|
Definition
- recombinant protein for CHO cells
- stimulates proliferation of erythroid precursors to increase RBC production
- used in anemia associated with chronic kidney failure |
|
|
Term
Darbepoetin alfa
(aranesp) |
|
Definition
- hypergylcosylated recombinant human erythropoesis stimulating protein
- 2nd generation of EPO
- 2 more carbohydrate chains
- increased potency and 3x half life
- used in anemia w/ chemotherapy or chronic kidney failure |
|
|
Term
|
Definition
| - stimulates megakarocytic progenitor cell and megakarocytes to platelets |
|
|
Term
GM-CSF
Granulocyte/macrophage Colony Stimulating Factor |
|
Definition
| - stimulates myeloid progenitor cell to produce red blood cells, platelets, macrophages, and neutrophils |
|
|
Term
G-CSF
Granulocyte Colony stimulating factor |
|
Definition
| - stimulates neutrophil progenitor cell to become a neutrophil |
|
|
Term
M CSF
Monocyte/ Macrophage Colony Stimulating Factor
|
|
Definition
| - stimulates the monocyte progenitor cell to become a monocyte |
|
|
Term
|
Definition
- interleukin 11
- stimulates platelet production |
|
|
Term
|
Definition
- acts as G CSF
- stimulates production of neutrophils |
|
|
Term
|
Definition
- chemical modification of filgrastim
- acts G CSF
- stimulates production of neutrophils |
|
|
Term
|
Definition
| - a major form of iron in vivo |
|
|
Term
|
Definition
- serum carrier globulin
- transfers iron from one place to another |
|
|
Term
|
Definition
- storage form of iron
- iron is bound to protein |
|
|
Term
|
Definition
- iron in vivo
- involved in oxygen reactions |
|
|
Term
|
Definition
- another protein carrier for iron
- associated with muscle tissues |
|
|
Term
|
Definition
- duodenal/proximal jujenal cells take up iron only in small amounts
- transferred to ferritin |
|
|
Term
|
Definition
- Ferrous sulfate
- Ferrous fumarate
- Ferrous gluconate |
|
|
