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Antianemia Drugs/Hematopoietic Growth Factors
Dr. Beevers
21
Pharmacology
Graduate
07/03/2011

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Cards

Term
ferrous fumarate
Definition
oral Fe therapy
Term
ferrous sulfate
Definition
oral Fe therapy
Term
ferrous gluconate
Definition
oral Fe therapy
Term
iron dextran
Definition
parenteral preparation used for iron deficiency anemia
-administered by deep intramuscular injection or IV (most common)
Term
sodium ferric gluconate complex
Definition
parenteral preparation used for iron deficiency anemia
-administered only by IV
Term
iron sucrose
Definition
parenteral preparation used for iron deficiency anemia
Term
adverse effects of oral Fe therapy
Definition
nausea
epigastric discomfort
abdominal cramps
constipation
diarrhea
black stool (no clinical significance - may hide blood loss diagnosis)
Term
adverse effects of parenteral Fe therapy
Definition
chronic treatment necessitates monitoring of Fe storage levels to avoid toxicity of iron overload
Term
acute Fe toxicity
Definition
seen in young children accidentally ingesting Fe tablets
-urgent treatment - flush out unabsorbed pills
-systemic administration of Fe antidote
Term
chronic Fe toxicity
Definition
Fe overload/hemochromatosis
organ failure/death
treat: intermittent phlebotomy in absence of anemia
-administration of iron antidote
Term
deferoxamine
Definition
Fe antidote (iron chelator)
-low oral availability
-administered IM and IV
-used in iron poisoning, transfusional Fe overload
Term
deferasirox
Definition
Fe antidote (tridentate iron chelator)
-administered orally
-used in chronic iron overload due to blood transfusions
Term
deoxyadenosylcobalamin
methylcobalamin
Definition
active form in humans
-can have various organic groups covalently bound to the cobalt atom; forms different cobalamins
-Vitamin B12
Term
Schilling test
Definition
allows determination of the mechanisms of the vitamin B12 deficiency
Term
cyanocobalamin
Definition
vitamin B12 preparation
-used in vitamin B12 deficiencies
Term
hydroxocobalamin
Definition
vitamin B12 preparation -used in vitamin B12 deficiencies -administered parenterally
Term
folic acid
Definition
treatment/prevention of megaloblastic anemia caused by folic acid deficiency
-administered orall
-prevents fetal neural tube defects (administered to pregnant women)
Term
leucovorin
Definition
blocks conversion of folic acid into dihydrofolate which depletes the folic acid cycle which halts DNA synthesis and in turn stops cell division
-"Leucovorin Rescue"
Term
epoetin alfa
Definition
used to treat anemia, primary bone marrow disorders, hemochromatosis... etc
-parenteral administration (3X/week)
Term
epoetin beta
Definition
1-2 doses/month
-long lived
used to treat anemia, primary bone marrow disorders, hemochromatosis... etc
-parenteral administration
Term
darbepoetin alfa
Definition
1 dose/week
used to treat anemia, primary bone marrow disorders, hemochromatosis... etc
-parenteral administration
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