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Definition
blocks Na+ channels tx of partial & tonic-clonic (generalized) seizures P450 inducer; incr dose gradually toxicity: nystagmus early, dose-limiting diplopia and ataxia, gingival hyperplasia & hirsutism (long-term use)
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Definition
ticyclic cpd tx for partial & tonic-clonic (generalized) seizures; also tx bipolar disorder & trigem neuralgia may exacerbate myoclonic & absence seizures Na+ channel blocker P450 inducer; adjust dose, avoid DDI's toxicity: nystagmus early, dose-limiting diplopia & ataxia Stevens-Johnson syndrome, 10X risk in asians
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Term
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Definition
tx partial seizures, tonic-clonic, myotonic, atonic, absence & combination seizures; also bipolar multiple MOA: block Na+ channels, potentiate GABA, inhibit histone deacetylase, etc. severe idiosyncratic hepatotoxicity
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Term
Which AED causes severe idiosyncratic hepatotoxicity and has broad specificity thought to be due to multiple MOA? |
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Definition
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| What are the drugs of choice to treat partial and tonic-clonic (generalized) seizures? |
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Definition
| Phenytoin, Carbamazepine, Valproic acid |
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| What are the drugs of choice for treating absence (generalized) seizures? |
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Definition
| Ethosuximide, Valproic acid, Clonazepam |
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Definition
first line for absence seizures only MOA: inhibits T-type Ca++ channel well absorbed toxicity: well tolerated; dose-related gastric distress
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Definition
tx for absence seizures (also infantile spasms plus some myoclonic & atonic seizures) benzodiazepine class use limited by sedation, tolerance dev, withdrawal
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| What is the treatment for generalized tonic-clonic status epilepticus? |
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