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Anti-rheumatics
UMKC SOM Pharmacology
23
Medical
Graduate
11/26/2013

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Cards

Term
NSAIDs
MOA
PK
AE
DI
Definition
Inhibit conversion of AA to PGs
Only give symptomatic relief, no disease mod
Lots of AE
Admin a PPI to prevent ulcer formation
Term
Corticosteroids
MOA
PK
AE
DI
Definition
Dec macrophages and IL-1, blocks phospholipase 1 to AA
Can be given in a shot
Can cause DM and osteoporosis
Best choice for pregnancy and bridging
Mostly used in end stage people
Term
Hydroxychlorquine
MOA
PK
AE
DI
Definition
Blocks T cells
Takes 3-6 months to onset, liver met, monitor ocular fxn
Macular damage and retinopathies
Best for mild RA
Term
Penicillamine
MOA
PK
AE
DI
Definition
Chelator of divalent cations, may effect PMNs
3 months, liver met
Rarely used due to tox: GI, blood, proteinuria, heavy metal dx
Term
Gold
MOA
PK
AE
DI
Definition
Macrophage and PMN fxn
4-6 m, mostly urine exc. IM > PO
Proteinuria, dermatitis, can slow dx, response generally good
Term
Methotrexate
MOA
PK
AE
DI
Definition
Inhibits DHFR, slows progression of RA, *Gold standard
4-6 weeks, renal excretion
Admin of folic acid can offset SE: stomatitis, myelosupression, hepatotox, plum tox, monitor LFTs, CBC, PFT
Interacts with sulfonamides, NSAIDs ad omeprazole
Term
Sulfaslazine
MOA
PK
AE
DI
Definition
Conjugate of sulfapridine and mesalamine, mild dx only
1-6 m, anorexia, dyspepsia, HA
Need folate supp
Term
Azithioprine
MOA
PK
AE
DI
Definition
Prodrug met to 6MC, blocks DNA and RNA synth, rarely used
Hep met xanthine oxidase,
dose related myelosuppression, somtatitis, skin rash
Dose reduce when using allopurinol
Term
Cyclosporine
MOA
PK
AE
DI
Definition
Blocks T cell activation, alt to methotrexate
Met CYP3A
Renal insufficiency
Term
Leflunomide
MOA
PK
AE
DI
Definition
Prodrug, blocks clonal expansion of act lymphocytes
As effective as methotrexate
Highly protein bound, renal, fecal slim
Hepatotx and teratogenic
Term
Infliximab
MOA
PK
AE
DI
Definition
Binds TNF-a, used in combo with MTX, fixes C and lyses cells
IV every 8 weeks, predisposition to infection
Term
Entanercept
MOA
PK
AE
DI
Definition
Human protein binds TNF, does not fix C or lyse cells
SQ weekly, predisposition to infection
Term
Ankinra
MOA
PK
AE
DI
Definition
Recombinant for IL-1, SQ daily
Infection
Term
Adalimumab
MOA
PK
AE
DI
Definition
TNF-a blocker, infection
Term
Abatacept
MOA
PK
AE
DI
Definition
Inhibits T cell activation, can't be taken with TNF blockers
Infection and lung cancer?
only used after failure of another drug
Term
Rituximab
MOA
PK
AE
DI
Definition
Binds CD20 on B cells, infection
Term
Tocilzumab
MOA
PK
AE
DI
Definition
IL-6 binding, infection
Term
Colchicine
MOA
PK
AE
DI
Definition
Acute gout, anti inflame spec for gout, blocks phag of irate crystals by neutrophils
Hepatic elim, narrow TR, agranulocytosis, TTP
Avoid: hepatic and renal impair, avoid in elderly
Term
Allopurinol
MOA
PK
AE
DI
Definition
XO blocker, blocks UA formation.
Renal dose adj. Effect in 1-3 weeks
Can make acute attack worse
Skin rash, HSN rxn, alopecia, leukopenia
Term
Febuxostat
MOA
PK
AE
DI
Definition
XO blocker, no renal dose adj
Cardiac SE, don't start acutely
For pts who can't take allopurinol
Term
Pegloticase
MOA
PK
AE
DI
Definition
Pegylated urate oxidase, for ppl who fail febuxostat
Term
Probenacid
MOA
PK
AE
DI
Definition
Uricosuric agent, blocks tubular reabsorption of irate
Only use if CrCL > 30
May exacerbate acute attack
Term
Sulfapyrazone
MOA
PK
AE
DI
Definition
Similar to Probenacid
Not well tolerated
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