Term
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Definition
aspirin Ticlodipine Clopidogrel abciximab eptifibatide tirofiban lamifiban dipyramidole |
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Term
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Definition
inhibit platelet agg -> inhibiting prostaglandins from arachidonic acid prolongs bleeding time |
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Term
| low dose effects of aspirin |
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Definition
| selectively inhibit TXA2 production |
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Term
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Definition
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Term
| CI/interactions of aspirin |
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Definition
| NOT W/ IBUPROFEN -> bind w/ COX and prevent the ability of aspirin to inhibit platelets |
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Term
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Definition
irreversibly inhibit platelet aggregation by blocking ADP receptors on platelet membrane -> inhibit expression of GPIIb/IIIa and fibrin binding |
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Term
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Definition
stroke pts who cant tolerate aspirin w/ aspirin to incr effectiveness (not approved) |
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Term
| how long does it take ticlodipine to work |
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Definition
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Term
which anti-platelet drugs are administered as prodrug? |
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Definition
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Term
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Definition
Protein bound c450 met slow abso w/ food |
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Term
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Definition
fatal neutropenia thrombocytopenic purpura rashes diarrhea |
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Term
what tests need to be monitored in a pt on ticlodipine |
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Definition
| CBC -> fatal neutropenia! |
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Term
| CI/interactions ticlodipine |
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Definition
hx of blood dyscrasias-> prolong PT thrombocytopenia, agranulocytosis, leukopenia lesions impaired liver fxn |
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Term
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Definition
irreversibly inhibit platelet agg. by blocking ADP receptors on platelet membrane-> inhibiting the expression of GPIIb/IIIa and fibrinogen binding! |
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Term
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Definition
same as ticlodipine prevent stroke in pts who cant tolerate aspirin w/ aspirin to incr effectiveness |
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Term
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Definition
c450 met oral 50% loading dose elim urine and feces |
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Term
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Definition
GI skin rashes (< ticlodipine) NO NEUTROPENIA!!!! |
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Term
| CI/interactions clopidogrel |
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Definition
SAFER than ticlodipine inhibits c450 |
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Term
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Definition
abciximab eptifibatide Tirofiban lamifiban dipyridamole |
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Term
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Definition
prevent platelet agg in PTCA pts or pts w/ acute coronary sx to reduce MI and incr revascularization ****only high risk pts**** |
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Term
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Definition
IV w/ aspirin and heparin w/i mins effects subside w/i days of d/c |
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Term
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Definition
monoclonal antibody->binds to GPIIb/IIIa -> prevents binding of fibrinogen & vWF aka no aggregation! |
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Term
| eptifibatide and tirofiban MOA |
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Definition
| Not monoclonal antibody -> works like abciximab |
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Term
which drugs have shorter DOA than abciximab |
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Definition
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Term
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Definition
| inhibits phosphodiesterase and incr. the prod of cAMP-> decr TXA-2 synth |
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Term
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Definition
specific, < use combined w/ warfarin in pts w/ prosthetic heart valves |
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