Term
| what are the three classes of alkylating agents? |
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Definition
Nitrogen Mustards
alkyl sulfonates
nitrosureas |
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Term
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Definition
| mechlorethamine, cyclophosphamide, ifosfamide, melphalan, chlorambucil |
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Term
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Definition
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Term
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Definition
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Term
| 2 properties of alkylating agents |
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Definition
mispairing of DNA bases (G binds with T) causing point mutation.
cross-linking (covalent link b/t DNA and proteins) |
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Term
| what is the effect of alkylating agents? |
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Definition
| proliferating cells. (not cytotoxic per se) |
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Term
| This alkylating agent is the least stable, rapidly metabolized |
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Definition
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Term
| This alkylating agent needs to activated by hepatic P450 |
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Definition
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Term
| method of activation of cyclophosphamide |
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Definition
| cyclo-->OHcyclo-->aldophos-->phosphoramide + acrolein |
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Term
| side effects of alkylating agents |
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Definition
myelosuppression
hemorrhagic cystitis
sterility
secondary leukemia |
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Term
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Definition
| daunorubicine, doxorubicin, idarubicin, mitoxantrone |
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Term
| Mech of Action for Anthracyclines |
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Definition
react with P450 to generate free radicals (requres presence of Iron)
intercalate into DNA (TOPO II inhibitors!) |
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Term
| This anthracycline produces fewer free radicals |
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Definition
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Term
| Anthracycline isolated from Strep veicillus |
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Definition
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Term
|
Definition
| free radical formation inducing DNA strand breaks |
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Term
| Dactinomycin mech of action |
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Definition
| intercalates b/t G-C pairs, blocking RNA polymerase |
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Term
| This drug alkylates DNA at the N6 of adenine and the N7 of guanine |
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Definition
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Term
| Side effects of anthracyclines |
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Definition
| Cardiotoxicity (D in middle of chest) |
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Term
| Drug with side effect of pulmonary fibrosis |
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Definition
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Term
| Side effect of Dactinomycin |
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Definition
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Term
| Side effects of Mitomycin C |
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Definition
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Term
| What are the 3 classes of antimetabolites |
|
Definition
Folic acid analogs
Pyrimidine analogs
Purine analogs |
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Term
| What's the folic acid analog |
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Definition
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Term
| what does methotrexate require for cytotoxic activity |
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Definition
| FPGS leading to depletion of critical folates |
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Term
| Mech of Act. for methotrexate |
|
Definition
inhibits DHFR and DNA and protein synthesis
thymidylate and purine synthesis |
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Term
| These are the pyrimidine analogs |
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Definition
5-FU
ara-C
2,2-difluorodeoxycytidine |
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Term
| Pyrimidine analog mech of action |
|
Definition
inhibit conversion of orotic acid to UMP
can be incorporated in either DNA or RNA |
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Term
| This pyrimidine analog causes inhibition of thymidine synthesis |
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Definition
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Term
| This pyrimidine analog can interfere w/DNA replication |
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Definition
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Term
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Definition
6-TG
6-MP
Fludarbine
2' deoxycoformycin
2' chlorodeoxyadenosine |
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Term
| Purine analogs that help convert to thioinosine to inhibit A-G |
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Definition
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Term
| This purine analong inhibits DNA poymerase, primase, and reductase |
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Definition
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Term
| This purine analog blocks adenosine deaminase and inhibits ribonucleotide |
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Definition
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Term
| antimetabolite that induces hemorrhagic cysitis |
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Definition
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Term
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Definition
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Term
|
Definition
| CD4 T cell depletion, peripheral neuropathy |
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Term
| side effect of 2' chlorodeoxyadenosine |
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Definition
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Term
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Definition
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Term
| Side effect of methotrexate |
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Definition
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Term
|
Definition
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Term
| DOC Hairy cell leukemia + Thrombocytopenia |
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Definition
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