Term
| This vinca alkaloid is not available for oral use |
|
Definition
|
|
Term
| This vinca alkaloid has poor penetration across the blood brain barrier and into the CSF |
|
Definition
|
|
Term
| How is resistance developed in vinca alkaloids? |
|
Definition
overexpression of the P170 glycoprotein
mutation in alpha and beta tubulin proteins |
|
|
Term
| Caution should be given in patients taking vinorebiline |
|
Definition
abnormal liver function
chemo/radiation therapy
breast feeding mothers |
|
|
Term
| Side effects if vinca alkaloids |
|
Definition
Neutropenia (most common)
nausea
GI toxic
Neurotoxicity
Myelosuppression |
|
|
Term
| This agents acts in late S and G2 phase of cell cycle by inhibiting TOPO II |
|
Definition
|
|
Term
| mech of resistance for etoposide |
|
Definition
| expression of P170 glycoprotein |
|
|
Term
| what is etoposide cross-resistant to |
|
Definition
| vinca alkaloids, anthracyclines, taxanes |
|
|
Term
| how is etoposide metabolized? |
|
Definition
| the liver via glucuronidation acid metabolites |
|
|
Term
|
Definition
Alopecia (most important)
Nausea
Anorexia
Myelosuppression |
|
|
Term
| what is the mech of resistance for Doxorubicin? |
|
Definition
increased expression of gene with P170 levels
increased expression of sulfhydryl proteins |
|
|
Term
| Side effects of Doxirubicin |
|
Definition
|
|
Term
| What is the mech of resistance for Bleomycin |
|
Definition
activation of bleomycin hydrolase
increased expression of DNA repair repair enzymes |
|
|
Term
| Doxorubicin mech of action |
|
Definition
| free radical intercalating w/DNA preventing replication |
|
|
Term
| how is bleomycin eliminated? |
|
Definition
|
|
Term
| Side effects of bleomycin |
|
Definition
|
|
Term
| what is the purpose of L-asparaginase? |
|
Definition
| hydrolyzes L-asparagine( starves tumor cells) |
|
|
Term
| what is the indication for L-asparginase |
|
Definition
| acute lymphocytic leukemia |
|
|
Term
| side effect of L-asparaginase |
|
Definition
Anaphylaxis
fever, chills
neuro
PANCREATITIS |
|
|
Term
| Alpha interferon mech of action |
|
Definition
|
|
Term
| How is alpha interferon absorbed? |
|
Definition
| Systemic circulation after IM or SC injection |
|
|
Term
| Major route of metabolism for alpha interferon |
|
Definition
|
|
Term
| what is alpha interferon contraindicated in |
|
Definition
| autoimmune disease, hepatitis |
|
|
Term
|
Definition
| stimulation of T cell immunity |
|
|
Term
| Cisplatin mechanism of action |
|
Definition
produces cross-links on DNA
binding to nuclear and cytoplasmic proteins. |
|
|
Term
| Does Cisplatin or Carboplatin cross the BBB? |
|
Definition
|
|
Term
|
Definition
nephrotoxicity
nausea
myelosuppression
neurotoxicity
OTOXICITY!!! |
|
|
Term
| Which drug is cleared by the kidney the fastest? Carbo or cis? |
|
Definition
| Carbo- 70% excreted w/i 24 hours |
|
|
Term
| Which is less toxic, Carboplatin or Cis |
|
Definition
|
|
Term
| mech of action for hydroxyurea |
|
Definition
activity in S phase
inhibits ribonucleotide reductase- decreasing DNA synthesis and repair |
|
|
Term
|
Definition
|
|
Term
| Vinca alkaloids cell cycle specificity |
|
Definition
|
|
Term
|
Definition
|
|
Term
| enzyme used to treat Acute lymphocytic leukemia |
|
Definition
|
|
Term
| These agents introduce cross-links at the A-G position |
|
Definition
| Cisplatin and Carboplastin |
|
|
Term
| Mech of action for Hydroxyurea |
|
Definition
| Inhibits ribonucleotide reductase |
|
|
