Term
|
Definition
mechlorethamine (alk. Agent)
carmustine/lomustine (nitrosureas)
dacarbazine/temozolomide/bendamustine (non-classical alk. Agents)
tretinoin (ATRA)
thalidomide/lenalidomide (anti-angiogen)
tositumomab (anti-CD20 + iodone)
erlotinib/gefitinb (internal TKIs) |
|
|
Term
|
Definition
carmustine/lomustine (nitrosureas)
BLEOMYCIN
cetuximab/pantumumab
erlotinib/gefitinb
trastuzumab |
|
|
Term
|
Definition
DOXORUBICIN
arsenic (prolongs QT)
cetuximab/panitumumab
erlotinib/gefitinb
nilotonib/dasatinib
sunitinb
TRASTUZUMAB |
|
|
Term
|
Definition
Causes Suppression
-carboplatin
-vinblastine
-METHOTREXATE
-etoposide (often used with bleomycin and cisplatin)
-5-FLUOROURACIL
-6-MERCAPTOPURINE
-6-TG
-bortezomib
-anti-CD20 Abs (rituximab, ibritumomab tiuxetan, tositumomab)
-anti-CD52 Ab (alemtuzumab)
No significant suppression (can be coupled with other drugs, i.e. etoposide)
-cisplatin
-bleomycin |
|
|
Term
| Crosses blood brain barries (thus good for brain cancers) |
|
Definition
|
|
Term
|
Definition
cisplatin
oxaloplatin
VINCRISTINE (PERIPHERAL NEUROPATHY) |
|
|
Term
|
Definition
|
|
Term
|
Definition
etoposide
hydroxyurea
gemcitabine
5-FU
anthracyclines |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
irinotecan (severe/fatal diarrhea)
bevacizumab (perforation) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| L-asparaginase (due to increased ammonia) |
|
|
Term
|
Definition
| Glucocorticoids (prednisone, dexamethasone) |
|
|
Term
|
Definition
| tositumomab (anti-CD20 Ab + iodine) |
|
|
Term
|
Definition
bevacizumab (anti-angiogenesis)
thalidomide/lealidomide (anti-angiogenesis)
tamoxifen (SERM)
fulvestrant (SERM)
toemifine (SERM)
raloxifene (SERM) |
|
|
Term
| Estrogen antagonist side effects (hot flashes, decreased bone density, nausea --> symptoms similar to menopause, i.e. loss of estrogen) |
|
Definition
tamoxifen (except increased bone density
fulvestrant
toremifene
raloxifene (except increased bone density)
aromatase inhibitors |
|
|
Term
| Estrogen agonist side effects |
|
Definition
-tamoxifen (increased risk of endometrial cancer, increased bone density, thrombophlebitis)
-NOT fulvestrant (except thrombophlebitis --> pure anti-estrogen)
-toremifene (increased risk of endometrial cancer, thrombophlebitis)
-raloxifen (NO ENDOMETRIAL CANCER, increased bone density, thrombophlebitis)
-NOT aromatase inhibitors |
|
|
Term
|
Definition
bicalutamide
flutamide
degarelix |
|
|
Term
| hot flashes (besides SERMs, aromatase inhibitors) |
|
Definition
prostate cancer drugs
-androgen receptor antagonists
-GnRH/LH agonists
-GnRH/LH antagonists |
|
|
Term
|
Definition
CYCLOPHOSPHAMIDE
ifosfamide |
|
|
Term
|
Definition
Chlorambucil
Melphalan
Cyclophosphamide
Ifosfamide
etoposide (topo II inhibitor) |
|
|
