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Anti-mycobacterial drugs
Drugs
9
Astronomy
4th Grade
12/11/2012

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Term
Isoniazid, Rifampin, Pyrazinamide, Ethambutal, Aminoglycosides, Fluoroquinolones, Cycloserine
Definition
Anti-mycobacterials
Term
most useful agent for treatment and prophylaxis of TB
Definition
Isoniazid
Term
Potent P450 inducer (many DIs!), undergoes enterohepatic circulation, main metabolism is deacetylation
Definition
Rifampin
Term
asynthetic analog of nicotinamide; tuberculocidal in replicating organism only; rapid resistance when used alone; dose-dependent hepatotoxicity
Definition
Pyrazinamide
Term
Tuberculostatic; also interacts physically with cell membrane; also used to treat M. avium intracellulare infections in AIDs
Definition
Ethambutol
Term
First line oral antituberculosis drugs
Definition
Isoniazid, Rifampicin, Ethambutol, Pyrazinamide, Rifabutin
Term
Injectable antituberculosis drugs
Definition
Kanamycin, Amikacin, Capreomycin, Streptomycin
Term
Fluoroquinolone Antituberculosis drugs
Definition
Levofloxacin, Moxifloxacin, Ofloxacin
Term
Oral bacteriostatic second-line antituberculosis drugs
Definition
Ethionamide, Protionamide, Cycloserine, Terizidone, P-aminosalicylic acid
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