Term
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Definition
Ergotamine
Anti-migraine ergot alkaloid
AA
alpha adrenergic agonist 5-HT1 antagonist
Rebound headaches, N&V,
contra in pregnancy and hypertension |
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Term
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Definition
Dihydroergotamine
Anti-migraine ergot alkaloid
AA alpha adrenergic antagonist 5-HT1 agonist Rebound headaches, N&V, contra in pregnancy and hypertension |
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Term
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Definition
Bromocriptine
Anti-migraine ergot alkaloid
AA
dopamine agonist
Rebound headaches, N&V,
contra in pregnancy and hypertension
(also in parkinsons) |
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Term
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Definition
Methysergide
Anti-migraine ergot alkaloid
Amine
5-HT2 antagonist
rebound headaches, N&V,
contra in pregnancy and hypertension |
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Term
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Definition
Sumatriptan
Anti-migraine
serotonin agonists 5-HT1b/1d agonist
SubQ > Oral
inhibit cGRP and vasodilation
s/e: sedation, N&V contra: heart disease |
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Term
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Definition
Zolmitriptan
Anti-migraine
serotonin agonists
less headache recurrence
better oral
longer duration |
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Term
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Definition
Naratriptan
Anti-migraine
serotonin agonists
more rapid
better oral
caution with liver disease |
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Term
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Definition
Rizatriptan
Anti-migraine
serotonin agonists
better oral, dissolves on tongue |
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Term
|
Definition
Treximet
Anti-migraine
Sumatriptan/Naproxen
5-HT1b/1d agonist + NSAID
constricts basilar artery and dura mater
inhibits synthesis of prostaglandins
no adrenergic/dopaminergic/muscarinic/benzo contra: cardiac, liver disease |
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