Term
| What are the five lipid lowering medication classes? |
|
Definition
HMG COA Reductase
Bile Acid Sequestrants
Niacin
Fibrates
Ezetimibe |
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|
Term
| What is the mechanism of bile acid sequestrants? |
|
Definition
| they are positively charged and easily bind te negatively charged bile acids thus requiring the liver to use more cholesterol to replace the removed bile acids |
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Term
| What type of medication is colestipol? |
|
Definition
|
|
Term
| What medications do bile acid sequestrants interfer with absorption? (4) |
|
Definition
warfarin
phenobarbital
digoxin
tetracycline |
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|
Term
| What are the two primary mechanisms of Niacin? |
|
Definition
inhibits lipolysis (HSL)
stimulates LPL |
|
|
Term
| What drug inhibits lipolysis? |
|
Definition
|
|
Term
| What is the primary biological effect of Niacin? |
|
Definition
|
|
Term
| What is the primary biological effect of fibrates? |
|
Definition
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|
Term
| What lipid lowering drug presents with flushing, pruritis, nausea and abdominal pain? |
|
Definition
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|
Term
| What medication can be taken with Niacin to lessen side effects? |
|
Definition
|
|
Term
| What are the side effects of Fibrates? |
|
Definition
|
|
Term
| What is the MOA of fibrates? |
|
Definition
|
|
Term
| What drug impairs cholesterol uptake by the brush border? |
|
Definition
|
|
Term
| What drug is used in stress testing when one cannot exercise? |
|
Definition
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|
Term
| What is the MOA of clopidogrel? |
|
Definition
inhibits ADP binding to PGY12
inhibits GPIIa/IIIb activation |
|
|
Term
| What are two uses of clopidogral? |
|
Definition
ASA allergy
percutaneous coronary intervention |
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|
Term
| What are the side effects of clopidogrel? (4) |
|
Definition
diarrhea
GI bleeding
neutropenia
heartburn |
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|
Term
| What are the side effects of Eptifibatide? (2) |
|
Definition
bleeding
thrombocytopenia |
|
|
Term
| What drug class includes eptifibatide? |
|
Definition
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|
Term
| How do the GPIIb/IIIa inhibitors have to be administered? |
|
Definition
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|
Term
| What can a beta blocker be used in that a non-dihydropuridine calcium channel blocker cannot be? (2) |
|
Definition
CHF
ventricular arrythmia |
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|
Term
| What can a calcium channel blocker be used for that a beta blocker cannot be? (1) |
|
Definition
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|
Term
| What drug will verapamil and dilitazem raise the serum levels of? |
|
Definition
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