Term
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Definition
Non-steroidal anti-inflammatory drugs
Suppress signs/symptoms of inflammation via inhibition of COX
Decreased inflammation, pain and fever |
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Term
Salicylates
Mechanism of action? |
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Definition
COX inhibition (reversible and irreversible)
Ab-Ag inhibition at high concentrations
Barrier formation → interfere with leukocyte migration
Block signal transduction in inflammatory cells |
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Term
Salicylates
Effect at low dose? Elimination? |
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Definition
Pain and fever relief
First order elimination |
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Term
Salicylates
Effect at high dose? Elimination? |
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Definition
Anti-inflammatory
Zero order elimination; enzymes become saturated |
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Term
Salicylates
Adverse Effects? |
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Definition
GI intolerance → inhibition of protective effects of prostaglandins
Increased formation of leukotrienes
Ulcer activity
Renal failure → RBF is regulated by PGs |
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Term
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Definition
PG analog
NSAIDs may cause ulcers
PG combats ulcer activity |
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Term
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Definition
Indole derivative
Efficacious COX inhibitor
Psychiatric effects, most commonly severe frontal headaches |
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Term
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Definition
COX inhibitor → analgesic, antipyretic, anti-inflammatory
T1/2 of naproxen is 14 hours
Longer lasting effect
Problematic for toxicities |
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Term
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Definition
COX inhibitor → analgesic, antipyretic, anti-inflammatory
T1/2 of ibuprofen = 2-6 hours |
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Term
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Definition
Disease-modifying antirheumatic drugs
Slow the progress of rheumatoid arthritis
Block/release cytokine action
Lose effect (5 year benefit)
Toxic to skin, blood, liver, kidney and eye |
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Term
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Definition
Structural analogue of folic acid
Interferes with purine synthesis and pro-inflammatory cytokines
Anti-cancer drug
Teratogenic, causes birth defects |
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Term
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Definition
Remicade
Monoclonal antibody to TNF-ɑ (pro-inflammatory cytokine)
IV infusion
Increased susceptibility to infection and lymphoma |
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Term
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Definition
Recombinant protein that fuses 2 TNF-ɑ receptors with IgG1
Subcutaneous
Increased susceptibility to infection and lymphoma |
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Term
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Definition
Monoclonal antibody, binds to CD20 on B cells
If anti-TNF-ɑ is ineffective |
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Term
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Definition
Inhibitor of JAK expressed in immune cells
JAK-STAT cytokine signalling inhibited → altered transcription of genes |
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Term
|
Definition
NSAID (anti-inflammatory) for acute gout attacks
Gout: sodium urate crystals in joints |
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Term
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Definition
Anti-inflammatory for gout arthritis
Depolymerization of microtubules in granulocytes → inhibit migration
GI toxicity: nausea, vomiting, diarrhea |
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Term
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Definition
Xanthine oxidase inhibitor, non-competitive
Most common treatment for long-term gout
Decrease uric acid formation |
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Term
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Definition
Xanthine oxidase inhibitor, non-competitive
Most common treatment for long-term gout
Decrease uric acid formation |
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Term
|
Definition
Uricosuric drug, organic acids
Inhibit renal tubular reabsorption of uric acid
Occupy anion transporter |
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Term
|
Definition
Uricosuric drug, organic acid
Inhibit renal tubular reabsorption of uric acid
Occupy anion transporter |
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