Term
Salicylates
Use
Mechanism
Adverse Effects
Kinetics |
|
Definition
Antithrombogenic
Irreversible COX inhibitor
Low dose - hyperuricemia
high dose - hypouricemia
Reyes syndrome
Overdose - CNS/hyperventilation/NVD
Zero order metabolism - worsen toxicity |
|
|
Term
Ibuprofen
Use
Mechanism
Adverse Effects
Availability |
|
Definition
Anitinflammatory
Antipyretic
osteo/RA analgesia
Dysmenorrhea
Reversible COX1>2 inhibition
Blurred vision
OTC |
|
|
Term
Naproxen
Use
Mechanism
availability
Kinetics |
|
Definition
Anitinflammatory
Antipyretic
osteo/RA analgesia
Dysmenorrhea
Reversible COX1>2 inhibition
OTC
long t1/2
Dose at night for AM stiffness |
|
|
Term
Indomethacin
Use
Mechanism
Adverse Effects
availability |
|
Definition
Reversal of acute disorders
Close patent ductus arteriosus
Acute gout attack
Reversible COX1>2 inhibition
Worse NSAID effects
Aplastic anemia
Pancreatitis
Vertigo
Rx |
|
|
Term
Piroxicam
Use
Mechanism
Adverse Effects
Metabolism |
|
Definition
Osteo/RA
Reversible COX1>2 inhibition
High dose - incr. GI ulcer risk
Long t1/2
More non-COX mediated antiinflammatory |
|
|
Term
Diclofenac
Use
Mechanism
Adverse Effects
Application |
|
Definition
Osteo/RA
Misc conditions
Reversible COX1>2 inhibition
Less GI ulcer risk (w/ misoprostol)
Elevated liver enzymes
Topical gel available |
|
|
Term
Sulindac
Use
Mechanism
Adverse Effects
Metabolism |
|
Definition
Osteo/RA
Gout
colorectal polyps in FAPolyposis
Reversible COX1>2 inhibition
Less GI ulcer risk
CNS effects up
Prodrug
Long t1/2
Enterohepatic recycling |
|
|
Term
Ketorolac
Use
Mechanism
Adverse Effects |
|
Definition
Analgesic (morphine alternative)
Reversible COX1>2 inhibition
Renal toxicity
Dont use >5 days |
|
|
Term
Nabumetone
Use
Mechanism
Adverse Effects
Metabolism |
|
Definition
Osteo/RA
Analgesic
Reversible COX1=2 inhibition
pseudoporphyria
photosensitivity
non-acid NSAID
Long t1/2 |
|
|
Term
Etodolac
Use
Mechanism
Adverse Effects |
|
Definition
Osteo/RA
reversible COX2>1 inhibition
Less GI ulcers |
|
|
Term
Celecoxib
Use
Mechanism
Adverse Effects |
|
Definition
Osteo/RA
colorectal polyps in FAPolyposis
reversible COX2 selective inhibition
Less GI ulcers
If already have ulcer - slow healing |
|
|
Term
Meloxicam
Use
Mechanism
Adverse Effects |
|
Definition
Osteo/RA
Reversible COX2 inhibition
high dose get COX1 inhibition also.
Less GI ulcers |
|
|
Term
Acetaminophen
Use
Mechanism
Adverse Effects |
|
Definition
Antipyretic
Analgesic
Reversible COX1=2 inhibitor
No GI/bleeding effects
Euphoria/dizziness/efficiency up
Hepatotoxicity (NAPQI) |
|
|
Term
NSAID
Actions - good and bad
7 sites |
|
Definition
GI-ulceration & gastric irritability (COX1)
Body temp-lessen fever (COX2)
Kidney-retain salt & H2O,
vasoconstriction
Ductus arteriosus-closure
Uterus-prolong labor
decrease constriction (cramps)
Airway-increase LT - airway constriction
CNS-dizzy,drowsy,confusion,anxiety,tinnitus |
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